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Cardiometabolic Risk Profiles of Adolescents Living With Perinatally Acquired HIV in South Africa.
Greybe, Leonore; Barnabas, Shaun; Cotton, Mark; Rose, Penelope; Rabie, Helena; Frigati, Lisa.
Afiliación
  • Greybe L; From the Department of Pediatrics and Child Health, Tygerberg Hospital, Stellenbosch University, Stellenbosch, South Africa.
  • Barnabas S; From the Department of Pediatrics and Child Health, Tygerberg Hospital, Stellenbosch University, Stellenbosch, South Africa.
  • Cotton M; Family Centre for Research with Ubuntu (FAM-CRU), Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Rose P; From the Department of Pediatrics and Child Health, Tygerberg Hospital, Stellenbosch University, Stellenbosch, South Africa.
  • Rabie H; Family Centre for Research with Ubuntu (FAM-CRU), Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Frigati L; From the Department of Pediatrics and Child Health, Tygerberg Hospital, Stellenbosch University, Stellenbosch, South Africa.
Pediatr Infect Dis J ; 43(7): 669-674, 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38535131
ABSTRACT

BACKGROUND:

We assessed the Pathological Determinants of Atherosclerosis in Youth (PDAY) score and other potential cardiovascular disease risk factors in adolescents previously enrolled in the Children with HIV Early antiRetroviral (CHER) and International Maternal Pediatric Adolescent AIDS Clinical Trials Network P1060 clinical trials.

METHODS:

Coronary artery and abdominal aorta (AA) PDAY scores were calculated for 56 participants over 15 years of age using a weighted combination of dyslipidemia, cigarette smoking, hypertension, obesity, and hyperglycemia. A PDAY score ≥1 is associated with early atherosclerosis.

RESULTS:

Fifty-six participants were enrolled 46 (82.1%) on a single-tablet regimen of tenofovir disoproxil fumarate, lamivudine and dolutegravir. Median time on antiretroviral therapy was 15.8 [interquartile range (IQR) 15.8-16.5] years and median time on dolutegravir was 14 (IQR 10.0-19.0) months. Fasting median high-density lipoprotein cholesterol was 20.1 mg/dL (IQR 16.0-23.7) and median non-high-density lipoprotein cholesterol was 38.3 mg/dL (IQR 30.8-44.3). The median systolic blood pressure was 115 mm Hg (IQR 107-121). Median body mass index was 21.3 kg/m 2 (IQR 19.5-24.7) and median fasted serum glucose was 82.0 mg/dL (IQR 75.7-87.3). Only 1 (2%) participant smoked cigarettes, but 5 (9%) smoked hookah pipe and 26 (46.4%) smoked cannabis. Thirty-one (55.4%) participants had coronary artery PDAY scores ≥1 and 33 (58.9%) had AA PDAY scores ≥1. Age was associated with an AA PDAY score ≥1 ( P = 0.02) with a 0.06 increase in AA PDAY score for every month of age (95% confidence interval 0.01-0.12, P = 0.01).

CONCLUSIONS:

Adolescents with perinatally acquired HIV appear at risk for cardiovascular disease. Specific tools for monitoring this risk are needed to institute appropriate preventive interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH Límite: Adolescent / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Pediatr Infect Dis J Asunto de la revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH Límite: Adolescent / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Pediatr Infect Dis J Asunto de la revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Estados Unidos