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Ductal Adenocarcinoma of the Prostate with Novel Genetic Alterations Characterized by Next-Generation Sequencing.
Zara Rozalen, Alexandra; Martin, Jose Manuel; Rajendran, Rithika; Jain, Maneesh; Nava, Victor E.
Afiliación
  • Zara Rozalen A; Department of Pathology, Veterans Affairs Medical Center, Washington, DC 20422, USA.
  • Martin JM; Department of Pathology, Mount Sinai Morningside and West Hospitals, New York, NY 10019, USA.
  • Rajendran R; Department of Pathology, Veterans Affairs Medical Center, Washington, DC 20422, USA.
  • Jain M; Department of Pathology, Veterans Affairs Medical Center, Washington, DC 20422, USA.
  • Nava VE; Section of Hematology & Oncology, Veterans Affairs Medical Center, Washington, DC 20422, USA.
Curr Oncol ; 31(3): 1556-1561, 2024 03 19.
Article en En | MEDLINE | ID: mdl-38534951
ABSTRACT
Ductal adenocarcinoma of the prostate (DAP) is an uncommon variant of prostate cancer associated with aggressive disease and poor outcome. It presents most frequently as a mixed tumor combined with acinar adenocarcinoma. Although the histopathological features of DAP are well known, its genomic characteristics are still evolving, prompting the suggestion that all DAP would benefit from molecular analysis with the purpose of improving tumor recognition, genetic classification, and, ultimately, personalized therapy. Herein, we report a case of DAP with novel genetic alterations (BCOR P1153S, ERG M219I, KDR A750E, POLE S1896P, and RAD21 T461del).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Carcinoma de Células Acinares / Carcinoma Ductal Límite: Humans / Male Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Carcinoma de Células Acinares / Carcinoma Ductal Límite: Humans / Male Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza