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ITGAV Promotes the Progression of Head and Neck Squamous Cell Carcinoma.
Xu, Lingyi; Barrett, Jeremy G; Peng, Jiayi; Li, Suk; Messadi, Diana; Hu, Shen.
Afiliación
  • Xu L; School of Dentistry, University of California, Los Angeles, CA 90095, USA.
  • Barrett JG; School of Dentistry, University of California, Los Angeles, CA 90095, USA.
  • Peng J; School of Dentistry, University of California, Los Angeles, CA 90095, USA.
  • Li S; School of Dentistry, University of California, Los Angeles, CA 90095, USA.
  • Messadi D; School of Dentistry, University of California, Los Angeles, CA 90095, USA.
  • Hu S; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90024, USA.
Curr Oncol ; 31(3): 1311-1322, 2024 03 01.
Article en En | MEDLINE | ID: mdl-38534932
ABSTRACT
Head and neck squamous cell carcinoma (HNSCC) refers to the malignancy of squamous cells in the head and neck region. Ranked as the seventh most common cancer worldwide, HNSCC has a very low survival rate, highlighting the importance of finding therapeutic targets for the disease. Integrins are cell surface receptors that play a crucial role in mediating cellular interactions with the extracellular matrix (ECM). Within this protein family, Integrin αV (ITGAV) has received attention for its important functional role in cancer progression. In this study, we first demonstrated the upregulation of ITGAV expression in HNSCC, with higher ITGAV expression levels correlating with significantly lower overall survival, based on TCGA (the Cancer Genome Atlas) and GEO datasets. Subsequent in vitro analyses revealed an overexpression of ITGAV in highly invasive HNSCC cell lines UM1 and UMSCC-5 in comparison to low invasive HNSCC cell lines UM2 and UMSCC-6. In addition, knockdown of ITGAV significantly inhibited the migration, invasion, viability, and colony formation of HNSCC cells. In addition, chromatin immunoprecipitation (ChIP) assays indicated that SOX11 bound to the promoter of ITGAV gene, and SOX11 knockdown resulted in decreased ITGAV expression in HNSCC cells. In conclusion, our studies suggest that ITGAV promotes the progression of HNSCC cells and may be regulated by SOX11 in HNSCC cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza