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In Silico Approach to Molecular Profiling of the Transition from Ovarian Epithelial Cells to Low-Grade Serous Ovarian Tumors for Targeted Therapeutic Insights.
Leblebici, Asim; Sancar, Ceren; Tercan, Bahar; Isik, Zerrin; Arayici, Mehmet Emin; Ellidokuz, Ender Berat; Basbinar, Yasemin; Yildirim, Nuri.
Afiliación
  • Leblebici A; Department of Translational Oncology, Institute of Health Sciences, Dokuz Eylul University, 35340 Izmir, Turkey.
  • Sancar C; Department of Gynecology and Obstetrics, Faculty of Medicine, Ege University, 35340 Izmir, Turkey.
  • Tercan B; Institute for Systems Biology, Seattle, WA 98109, USA.
  • Isik Z; Department of Computer Engineering, Faculty of Engineering, Dokuz Eylul University, 35340 Izmir, Turkey.
  • Arayici ME; Department of Public Health, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey.
  • Ellidokuz EB; Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey.
  • Basbinar Y; Department of Translational Oncology, Institute of Oncology, Dokuz Eylul University, 35340 Izmir, Turkey.
  • Yildirim N; Department of Gynecology and Obstetrics, Faculty of Medicine, Ege University, 35340 Izmir, Turkey.
Curr Issues Mol Biol ; 46(3): 1777-1798, 2024 Feb 26.
Article en En | MEDLINE | ID: mdl-38534733
ABSTRACT
This paper aims to elucidate the differentially coexpressed genes, their potential mechanisms, and possible drug targets in low-grade invasive serous ovarian carcinoma (LGSC) in terms of the biologic continuity of normal, borderline, and malignant LGSC. We performed a bioinformatics analysis, integrating datasets generated using the GPL570 platform from different studies from the GEO database to identify changes in this transition, gene expression, drug targets, and their relationships with tumor microenvironmental characteristics. In the transition from ovarian epithelial cells to the serous borderline, the FGFR3 gene in the "Estrogen Response Late" pathway, the ITGB2 gene in the "Cell Adhesion Molecule", the CD74 gene in the "Regulation of Cell Migration", and the IGF1 gene in the "Xenobiotic Metabolism" pathway were upregulated in the transition from borderline to LGSC. The ERBB4 gene in "Proteoglycan in Cancer", the AR gene in "Pathways in Cancer" and "Estrogen Response Early" pathways, were upregulated in the transition from ovarian epithelial cells to LGSC. In addition, SPP1 and ITGB2 genes were correlated with macrophage infiltration in the LGSC group. This research provides a valuable framework for the development of personalized therapeutic approaches in the context of LGSC, with the aim of improving patient outcomes and quality of life. Furthermore, the main goal of the current study is a preliminary study designed to generate in silico inferences, and it is also important to note that subsequent in vitro and in vivo studies will be necessary to confirm the results before considering these results as fully reliable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Issues Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza