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Activin E is a transforming growth factor ß ligand that signals specifically through activin receptor-like kinase 7.
Vestal, Kylie A; Kattamuri, Chandramohan; Koyiloth, Muhasin; Ongaro, Luisina; Howard, James A; Deaton, Aimee M; Ticau, Simina; Dubey, Aditi; Bernard, Daniel J; Thompson, Thomas B.
Afiliación
  • Vestal KA; Department of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45267, U.S.A.
  • Kattamuri C; Department of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45267, U.S.A.
  • Koyiloth M; Department of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45267, U.S.A.
  • Ongaro L; Department of Pharmacology and Therapeutics, Centre for Research in Reproduction and Development, McGill University, Montreal, Quebec, Canada.
  • Howard JA; Department of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH 45267, U.S.A.
  • Deaton AM; Alnylam Pharmaceuticals, Cambridge, MA, U.S.A.
  • Ticau S; Alnylam Pharmaceuticals, Cambridge, MA, U.S.A.
  • Dubey A; Alnylam Pharmaceuticals, Cambridge, MA, U.S.A.
  • Bernard DJ; Department of Pharmacology and Therapeutics, Centre for Research in Reproduction and Development, McGill University, Montreal, Quebec, Canada.
  • Thompson TB; Department of Molecular and Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45267, U.S.A.
Biochem J ; 481(7): 547-564, 2024 Apr 10.
Article en En | MEDLINE | ID: mdl-38533769
ABSTRACT
Activins are one of the three distinct subclasses within the greater Transforming growth factor ß (TGFß) superfamily. First discovered for their critical roles in reproductive biology, activins have since been shown to alter cellular differentiation and proliferation. At present, members of the activin subclass include activin A (ActA), ActB, ActC, ActE, and the more distant members myostatin and GDF11. While the biological roles and signaling mechanisms of most activins class members have been well-studied, the signaling potential of ActE has remained largely unknown. Here, we characterized the signaling capacity of homodimeric ActE. Molecular modeling of the ligandreceptor complexes showed that ActC and ActE shared high similarity in both the type I and type II receptor binding epitopes. ActE signaled specifically through ALK7, utilized the canonical activin type II receptors, ActRIIA and ActRIIB, and was resistant to the extracellular antagonists follistatin and WFIKKN. In mature murine adipocytes, ActE invoked a SMAD2/3 response via ALK7, like ActC. Collectively, our results establish ActE as a specific signaling ligand which activates the type I receptor, ALK7.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Factor de Crecimiento Transformador beta Límite: Animals Idioma: En Revista: Biochem J Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Factor de Crecimiento Transformador beta Límite: Animals Idioma: En Revista: Biochem J Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido