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An LC-MS/MS method for the determination of drugs of abuse included THC-COOH, EtG, and NPS, using a single hair extraction sample.
Longo, Valentina; Stocchero, Giulia; Lucchiari, Manuela; Marchio, Giovanni Michele; Donini, Flora; Ingenito, Francesco; Bertoldi, Lucia; Pecoraro, Lucia; Anesi, Adriano; Favretto, Donata.
Afiliación
  • Longo V; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Stocchero G; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Lucchiari M; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Marchio GM; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Donini F; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Ingenito F; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Bertoldi L; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Pecoraro L; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Anesi A; Toxicology Division, U.O.C. Clinical Pathology, APSS, Trento, Italy.
  • Favretto D; Legal Medicine and Toxicology, University Hospital of Padova, Padova, Italy.
Drug Test Anal ; 2024 Mar 26.
Article en En | MEDLINE | ID: mdl-38532552
ABSTRACT
Hair analysis plays an important role in the determination of drugs of abuse in both forensic and clinical toxicology investigations. The analysis of different substances often requires the use of different sample preparation methods, thereby increasing the amount of hair sample and time required. In the present study, a fast method involving a combination of a single 25 mg hair extraction procedure and four liquid chromatography-tandem mass spectrometry methods using the same chromatographic phases and column was developed and validated. The target was the identification and quantification of various commonly abused drugs and their metabolites, including amphetamines, cocaine, opioids, cannabinoids, THC-COOH and EtG, and more than 140 new psychoactive substances, including synthetic cannabinoids, phenethylamines, synthetic opioids, methylphenidate, cathinone, piperidine, and tryptamines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Drug Test Anal Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Drug Test Anal Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido