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Survival in pregnancy-associated breast cancer patients compared to non-pregnant controls.
Martín Cameán, María; Jaunarena, Ibon; Sánchez-Méndez, Jose Ignacio; Martín, Covadonga; Boria, Félix; Martín, Elena; Spagnolo, Emanuela; Zapardiel, Ignacio; Hernández Gutiérrez, Alicia.
Afiliación
  • Martín Cameán M; Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, 28046, Spain. Mariamartincamean@gmail.com.
  • Jaunarena I; Gynecologic Oncology Unit, Department of Gynecology and Obstetrics, Donostia University Hospital, San Sebastian, 20014, Spain.
  • Sánchez-Méndez JI; Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, 28046, Spain.
  • Martín C; Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, 28046, Spain.
  • Boria F; Clínica Universidad de Navarra, Madrid, 28027, Spain.
  • Martín E; Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, 28046, Spain.
  • Spagnolo E; Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, 28046, Spain.
  • Zapardiel I; Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, 28046, Spain.
  • Hernández Gutiérrez A; Department of Gynecology and Obstetrics, La Paz University Hospital, Madrid, 28046, Spain.
Reprod Biol Endocrinol ; 22(1): 34, 2024 Mar 26.
Article en En | MEDLINE | ID: mdl-38532462
ABSTRACT

BACKGROUND:

Pregnancy-associated breast cancer (PABC) is a rare entity whose prognosis has previously been studied and is subject to controversy.

METHODS:

Survival of patients with PABC diagnosed between 2009 and 2021 with breast cancer during pregnancy or until 1 year after childbirth was compared with non-pregnant patients with breast cancer from the same period at La Paz University Hospital. Cox proportional hazards regression was used to compare disease-free (DFS) and overall (OS) survival between the groups, adjusting for grade and pathologic stage.

RESULTS:

Among the 89 included patients with breast cancer, 34 were diagnosed during pregnancy, and 55 were not pregnant. The pregnant patients were more likely to have grade 3 tumors (61.3% vs 37%, p = 0.023) and an advanced stage (pathologic stage III-IV 44.1% vs 17.6%, p = 0.008). Median follow-up was 47 months for the pregnant group and 46 months for the control group. After adjustments for tumor grade and pathologic stage, OS was comparable between the groups (HR 2.03; 95% CI 0.61 to 6.79; P = 0.25).

CONCLUSIONS:

The outcome of women diagnosed with PABC is comparable to young non-pregnant controls. However, it should be taken into account that PABC has a more aggressive phenotype.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Neoplásicas del Embarazo / Propanolaminas / Azidas / Neoplasias de la Mama Límite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Biol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Neoplásicas del Embarazo / Propanolaminas / Azidas / Neoplasias de la Mama Límite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Biol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido