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Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali.
Doucoure, M'Bouye; Zeguime, Amatigue; Niangaly, Amadou; Guindo, Merepen A; Doritchamou, Justin Y A; Assadou, Mahamadoun H; Katile, Abdoulaye; Kanoute, Moussa B; Perou, Sidiki; Ouattara, Adama; Sanogo, Sintry; Ouologuem, Boucary; Traore, Souleymane; Dao, Bakary; Dembele, Drissa; Kone, Mamady; Kamate, Bourama; Sissoko, Kourane; Sankare, Seydou; Diarra, Sadio; Dolo, Amagana; Sissoko, Mahamadou S; Hume, Jennifer C C; Cook, David; Healy, Sara A; Gorres, J Patrick; Traoré, Boubacar; Gamiel, Jordyn; Duffy, Patrick E; Sagara, Issaka.
Afiliación
  • Doucoure M; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Zeguime A; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Niangaly A; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Guindo MA; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Doritchamou JYA; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Assadou MH; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Katile A; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Kanoute MB; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Perou S; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Ouattara A; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Sanogo S; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Ouologuem B; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Traore S; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Dao B; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Dembele D; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Kone M; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Kamate B; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Sissoko K; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Sankare S; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Diarra S; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Dolo A; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Sissoko MS; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Hume JCC; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Cook D; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Healy SA; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Gorres JP; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Traoré B; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
  • Gamiel J; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Duffy PE; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
  • Sagara I; Malaria Research and Training Center, International Center for Excellence in Research-MALI, University of Sciences, Techniques and Technologies of Bamako, Mali.
Am J Trop Med Hyg ; 110(5): 1021-1028, 2024 May 01.
Article en En | MEDLINE | ID: mdl-38531104
ABSTRACT
The interpretation of a laboratory test result requires an appropriate reference range established in healthy subjects, and normal ranges may vary by factors such as geographic region, sex, and age. We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy population. In fact, 30.4% of adult participants had abnormal neutrophil levels and 19.8% had abnormal hemoglobin levels. Differences by sex were observed in those who were older, but not in those younger than 10 years, for several parameters, including hemoglobin, platelet, and absolute neutrophil counts in hematology, and creatinine in biochemistry. The site-specific reference intervals we report can be used in malaria vaccine clinical trials and other interventional studies, as well as in routine clinical care, to identify abnormalities in hematological and biochemical parameters among healthy Malian trial participants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Rural Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Am J Trop Med Hyg Año: 2024 Tipo del documento: Article País de afiliación: Mali Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Rural Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Africa Idioma: En Revista: Am J Trop Med Hyg Año: 2024 Tipo del documento: Article País de afiliación: Mali Pais de publicación: Estados Unidos