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Low Cubilin/Myeloperoxidase ratio as a promising biomarker for prognosis of high-grade T1 bladder cancer.
Silva Medeiros, Mariana; Botelho de Carvalho, Luís André; Alves, Marta; Papoila, Ana; Baptista Carreira Dos Santos, Hugo Miguel; Capelo-Martínez, José-Luis; Viegas de Campos Pinheiro, Luís Manuel.
Afiliación
  • Silva Medeiros M; Department of Urology, Central Lisbon University Hospital Centre, Lisbon, Portugal. mmariana.medeiros92@gmail.com.
  • Botelho de Carvalho LA; Department of Chemistry, Faculty of Science and Technology, Caparica, Portugal.
  • Alves M; Epidemiology and Statistics Unit, Research Centre, Central Lisbon University Hospital Centre, Lisbon, Portugal.
  • Papoila A; Epidemiology and Statistics Unit, Research Centre, Central Lisbon University Hospital Centre, Lisbon, Portugal.
  • Baptista Carreira Dos Santos HM; Department of Chemistry, Faculty of Science and Technology, Caparica, Portugal.
  • Capelo-Martínez JL; Department of Chemistry, Faculty of Science and Technology, Caparica, Portugal.
  • Viegas de Campos Pinheiro LM; Department of Urology, Central Lisbon University Hospital Centre, Lisbon, Portugal.
Int Urol Nephrol ; 56(8): 2577-2587, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38530585
ABSTRACT

PURPOSE:

T1 bladder cancer is known for its high progression and recurrence rates. Identifying aggressive tumours at the non-muscle-invasive stage is crucial to allow early interventions and subsequently increase patient survival. This study aimed to investigate the potential of the cubilin/myeloperoxidase (CUBN/MPO) ratio as a high-grade T1 bladder cancer biomarker.

METHODS:

Urine samples were collected from 30 patients who underwent transurethral resection of the tumour with high-grade T1 bladder cancer (June 2015 to December 2019) before surgery. The urinary proteome was analysed using high-resolution mass spectrometry and the CUBN/MPO ratio was calculated. The primary outcome was the recurrence during the follow-up (around 31.5 months after resection). Univariate Cox regression and Kaplan-Meier curves were used for data analysis.

RESULTS:

Patients with a low CUBN/MPO ratio exhibited upregulated MPO and/or downregulated CUBN. This group of patients had a higher incidence of disease recurrence and progression. Low CUBN/MPO ratio was significantly associated with a higher likelihood of recurrence, progression, and death. It is worth noting that this study was exploratory and conducted on a small sample size, so further research is needed to validate these findings in larger cohorts.

CONCLUSION:

This study highlights the potential of the CUBN/MPO ratio as a prognostic biomarker for high-grade T1 bladder cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Biomarcadores de Tumor / Peroxidasa / Clasificación del Tumor / Estadificación de Neoplasias Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int Urol Nephrol Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Biomarcadores de Tumor / Peroxidasa / Clasificación del Tumor / Estadificación de Neoplasias Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int Urol Nephrol Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Países Bajos