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Association Between Pancreatic Cysts and Diabetes Mellitus in Von Hippel-Lindau Disease.
Onishi, Yasuyuki; Shimizu, Hironori; Koyasu, Sho; Taura, Daisuke; Takahashi, Ayako; Uza, Norimitsu; Isoda, Hiroyoshi; Nakamoto, Yuji.
Afiliación
  • Onishi Y; Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, JPN.
  • Shimizu H; Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, JPN.
  • Koyasu S; Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, JPN.
  • Taura D; Von Hippel-Lindau Disease (VHL) Center, Kyoto University Hospital, Kyoto, JPN.
  • Takahashi A; Diabetes, Endocrinology and Nutrition, Kyoto University, Kyoto, JPN.
  • Uza N; Von Hippel-Lindau Disease (VHL) Center, Kyoto University Hospital, Kyoto, JPN.
  • Isoda H; Ophthalmology, Kyoto University, Kyoto, JPN.
  • Nakamoto Y; Von Hippel-Lindau Disease (VHL) Center, Kyoto University Hospital, Kyoto, JPN.
Cureus ; 16(2): e54781, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38529425
ABSTRACT

INTRODUCTION:

Pancreatic cysts are frequently observed in patients with von Hippel-Lindau disease (VHL), and they are considered clinically not important. This study aimed to evaluate the association between pancreatic cysts and diabetes mellitus (DM) in patients with VHL.

METHODS:

Among patients who were on a patient list at the VHL Center at Kyoto University Hospital as of December 2022, those who had undergone an upper abdominal magnetic resonance imaging study after 2010 were retrospectively evaluated. The presence or absence of DM and high glycated hemoglobin (HbA1c) levels (>6.0%) were assessed. Patients were divided into two groups those with DM or high HbA1c levels, and those without DM or high HbA1c levels. The area of the whole pancreas, including the pancreatic cysts and tumors, the area of the pancreatic cysts, and the percentage of pancreatic cysts, calculated by dividing the area of pancreatic cysts by the area of the whole pancreas, were measured on T2-weighted magnetic resonance images and compared between the two groups.

RESULTS:

Thirty-six patients with VHL, comprising 22 men and 14 women, with a mean age of 36.4 years (range, 11-79 years), were identified. Seven patients had DM, and two additional patients had high HbA1c levels. The area of the pancreatic cysts (p = 0.0013) was significantly larger and the percentage of the pancreatic cysts (p = 0.0016) was significantly higher in patients with DM or high HbA1c levels (n = 9) than in patients without DM or high HbA1c levels (n = 27); however, the difference in the area of the whole pancreas was not significant (p = 0.068).

CONCLUSION:

Our findings suggest that patients with VHL who have a large area covered by pancreatic cysts are more likely to have DM than those without.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos