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Oral and gut microbial profiling in periodontitis and Parkinson's disease.
Yay, Ekin; Yilmaz, Melis; Toygar, Hilal; Balci, Nur; Alvarez Rivas, Carla; Bolluk Kiliç, Basak; Zirh, Ali; Paster, Bruce J; Kantarci, Alpdogan.
Afiliación
  • Yay E; Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USA.
  • Yilmaz M; Periodontist, Private Practice, Istanbul, Turkey.
  • Toygar H; Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USA.
  • Balci N; Department of Periodontology, Istanbul Medipol University, Istanbul, Turkey.
  • Alvarez Rivas C; Department of Periodontology, Istanbul Medipol University, Istanbul, Turkey.
  • Bolluk Kiliç B; Department of Periodontology, Istanbul Medipol University, Istanbul, Turkey.
  • Zirh A; Department of Applied Oral Sciences, The ADA Forsyth Institute, Cambridge, MA, USA.
  • Paster BJ; Department of Oral Microbiology and Infection, Harvard School of Dental Medicine, Boston, MA, USA.
  • Kantarci A; Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.
J Oral Microbiol ; 16(1): 2331264, 2024.
Article en En | MEDLINE | ID: mdl-38528960
ABSTRACT

Objectives:

We tested the hypothesis that Parkinson's disease (PA) alters the periodontitis-associated oral microbiome.

Method:

Patients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed.

Results:

PA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversity between HC and PA+P (p = 0.001), HC and P (p = 0.001), and P and PA+P (p = 0.028). The microbial profiles of saliva and fecal samples were distinct. Mycoplasma faucium, Tannerella forsythia, Parvimonas micra, and Saccharibacteria (TM7) were increased in P; Prevotella pallens, Prevotella melaninogenica, Neisseria multispecies were more abundant in PA+P group, Ruthenibacterium lactatiformans, Dialister succinatiphilus, Butyrivibrio crossotus and Alloprevotella tannerae were detected in fecal samples in P groups compared to healthy controls.

Conclusions:

No significant differences were detected between Parkinson's and non-Parkinson's gut microbiomes, suggesting that Parkinson's disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Oral Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Oral Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos