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Correlations between serum kidney injury molecule-1, cystatin C and immunosuppressants: A cross-sectional study of renal transplant patients in Bahrain.
Sridharan, Kannan; Shah, Shamik; Hammad, Mona Al; Mohammed, Fatima Ali; Veeramuthu, Sindhan; Taher, Mona Abdulla; Hammad, Mustafa Mohamed; Jawad, Lamees; Farid, Eman.
Afiliación
  • Sridharan K; Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.
  • Shah S; Department of Nephrology, Salmaniya Medical Complex, Manama, Kingdom of Bahrain.
  • Hammad MA; Department of Internal Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.
  • Mohammed FA; Salmaniya Medical Complex, Manama, Kingdom of Bahrain.
  • Veeramuthu S; Department of Nephrology, Salmaniya Medical Complex, Manama, Kingdom of Bahrain.
  • Taher MA; Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.
  • Hammad MM; Department of Nephrology, Salmaniya Medical Complex, Manama, Kingdom of Bahrain.
  • Jawad L; Salmaniya Medical Complex, Manama, Kingdom of Bahrain.
  • Farid E; Department of Laboratory Medicine, Salmaniya Medical Complex, Manama, Kingdom of Bahrain.
J Biomed Res ; 38(3): 269-277, 2024 Mar 26.
Article en En | MEDLINE | ID: mdl-38528676
ABSTRACT
Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for treatment. Serum creatinine is the standard for monitoring kidney function; however, cystatin C (Cys C) and kidney injury molecule-1 (KIM-1) have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney function. Here, we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil, tacrolimus, sirolimus, everolimus, or cyclosporine to evaluate kidney function. We used both the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 equation, which is based on creatinine and combined creatinine with Cys C, and the CKD-EPI 2012 equation, which is based on Cys C alone, to estimate glomerular filtration rate (GFR). Then, we assessed the association between serum KIM-1 and GFR < 90 mL per minute per 1.73 m 2. We observed significantly higher serum Cys C levels in patients with the elevated serum creatinine, compared with those with normal serum creatinine. The estimated GFRs based on creatinine were significantly higher than those based on the other equations, while a significant positive correlation was observed among all equations. Serum KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations. A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR < 90 mL per minute per 1.73 m 2. We observed a significant correlation between serum creatinine and Cys C in our renal transplant patients. Therefore, serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Biomed Res Año: 2024 Tipo del documento: Article Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Biomed Res Año: 2024 Tipo del documento: Article Pais de publicación: China