Your browser doesn't support javascript.
loading
Integration of polygenic and gut metagenomic risk prediction for common diseases.
Liu, Yang; Ritchie, Scott C; Teo, Shu Mei; Ruuskanen, Matti O; Kambur, Oleg; Zhu, Qiyun; Sanders, Jon; Vázquez-Baeza, Yoshiki; Verspoor, Karin; Jousilahti, Pekka; Lahti, Leo; Niiranen, Teemu; Salomaa, Veikko; Havulinna, Aki S; Knight, Rob; Méric, Guillaume; Inouye, Michael.
Afiliación
  • Liu Y; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. yl985@medschl.cam.ac.uk.
  • Ritchie SC; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. yl985@medschl.cam.ac.uk.
  • Teo SM; Department of Clinical Pathology, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia. yl985@medschl.cam.ac.uk.
  • Ruuskanen MO; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK. yl985@medschl.cam.ac.uk.
  • Kambur O; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. yl985@medschl.cam.ac.uk.
  • Zhu Q; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Sanders J; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
  • Vázquez-Baeza Y; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.
  • Verspoor K; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Jousilahti P; British Heart Foundation Cambridge Centre of Research Excellence, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
  • Lahti L; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
  • Niiranen T; Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Salomaa V; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
  • Havulinna AS; Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
  • Knight R; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Méric G; Department of Computing, University of Turku, Turku, Finland.
  • Inouye M; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Nat Aging ; 4(4): 584-594, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38528230
ABSTRACT
Multiomics has shown promise in noninvasive risk profiling and early detection of various common diseases. In the present study, in a prospective population-based cohort with ~18 years of e-health record follow-up, we investigated the incremental and combined value of genomic and gut metagenomic risk assessment compared with conventional risk factors for predicting incident coronary artery disease (CAD), type 2 diabetes (T2D), Alzheimer disease and prostate cancer. We found that polygenic risk scores (PRSs) improved prediction over conventional risk factors for all diseases. Gut microbiome scores improved predictive capacity over baseline age for CAD, T2D and prostate cancer. Integrated risk models of PRSs, gut microbiome scores and conventional risk factors achieved the highest predictive performance for all diseases studied compared with models based on conventional risk factors alone. The present study demonstrates that integrated PRSs and gut metagenomic risk models improve the predictive value over conventional risk factors for common chronic diseases.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Enfermedad de la Arteria Coronaria / Diabetes Mellitus Tipo 2 Límite: Humans / Male Idioma: En Revista: Nat Aging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Enfermedad de la Arteria Coronaria / Diabetes Mellitus Tipo 2 Límite: Humans / Male Idioma: En Revista: Nat Aging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos