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Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging.
Meador, William E; Lin, Eric Y; Lim, Irene; Friedman, Hannah C; Ndaleh, David; Shaik, Abdul K; Hammer, Nathan I; Yang, Boqian; Caram, Justin R; Sletten, Ellen M; Delcamp, Jared H.
Afiliación
  • Meador WE; University of Mississippi, Department of Chemistry and Biochemistry, Oxford, MS, USA.
  • Lin EY; University of California Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, USA.
  • Lim I; University of California Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, USA.
  • Friedman HC; University of California Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, USA.
  • Ndaleh D; University of Mississippi, Department of Chemistry and Biochemistry, Oxford, MS, USA.
  • Shaik AK; University of Mississippi, Department of Chemistry and Biochemistry, Oxford, MS, USA.
  • Hammer NI; University of Mississippi, Department of Chemistry and Biochemistry, Oxford, MS, USA.
  • Yang B; HORIBA Scientific, Piscataway, NJ, USA.
  • Caram JR; University of California Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, USA.
  • Sletten EM; University of California Los Angeles, Department of Chemistry and Biochemistry, Los Angeles, CA, USA. Sletten@chem.ucla.edu.
  • Delcamp JH; University of Mississippi, Department of Chemistry and Biochemistry, Oxford, MS, USA. delcamp@olemiss.edu.
Nat Chem ; 16(6): 970-978, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38528102
ABSTRACT
In vivo fluorescence imaging in the shortwave infrared (SWIR, 1,000-1,700 nm) and extended SWIR (ESWIR, 1,700-2,700 nm) regions has tremendous potential for diagnostic imaging. Although image contrast has been shown to improve as longer wavelengths are accessed, the design and synthesis of organic fluorophores that emit in these regions is challenging. Here we synthesize a series of silicon-RosIndolizine (SiRos) fluorophores that exhibit peak emission wavelengths from 1,300-1,700 nm and emission onsets of 1,800-2,200 nm. We characterize the fluorophores photophysically (both steady-state and time-resolved), electrochemically and computationally using time-dependent density functional theory. Using two of the fluorophores (SiRos1300 and SiRos1550), we formulate nanoemulsions and use them for general systemic circulatory SWIR fluorescence imaging of the cardiovascular system in mice. These studies resulted in high-resolution SWIR images with well-defined vasculature visible throughout the entire circulatory system. This SiRos scaffold establishes design principles for generating long-wavelength emitting SWIR and ESWIR fluorophores.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silicio / Imagen Óptica / Colorantes Fluorescentes / Rayos Infrarrojos Límite: Animals Idioma: En Revista: Nat Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silicio / Imagen Óptica / Colorantes Fluorescentes / Rayos Infrarrojos Límite: Animals Idioma: En Revista: Nat Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido