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Simultaneous determination of 28 illegal drugs in sewage by high throughput online SPE-ISTD-UHPLC-MS/MS.
Chen, Shunqin; Yang, Han; Zhang, Shan; Zhu, Faze; Liu, Shan; Gao, Huan; Diao, Qing; Ding, Wenbo; Chen, Yuemeng; Luo, Peng; Liu, Yubo.
Afiliación
  • Chen S; Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou Province, 550001, China.
  • Yang H; Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou Province, 550001, China.
  • Zhang S; Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou Province, 550001, China.
  • Zhu F; Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou Province, 550001, China.
  • Liu S; Guiyang City Public Security Bureau Drug Testing Center, Guiyang, Guizhou Province, 550008, China.
  • Gao H; Guiyang City Public Security Bureau Drug Testing Center, Guiyang, Guizhou Province, 550008, China.
  • Diao Q; Guizhou Wanfu Xianyi Testing Technology Co., Ltd, Guiyang, Guizhou Province, 550009, China.
  • Ding W; Guizhou Wanfu Xianyi Testing Technology Co., Ltd, Guiyang, Guizhou Province, 550009, China.
  • Chen Y; Guiyang City Public Security Bureau Drug Testing Center, Guiyang, Guizhou Province, 550008, China.
  • Luo P; Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou Province, 550001, China.
  • Liu Y; Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou Province, 550001, China.
Heliyon ; 10(6): e27897, 2024 Mar 30.
Article en En | MEDLINE | ID: mdl-38524584
ABSTRACT
This study developed an online solid-phase extraction ultra-high performance liquid chromatography-tandem mass spectrometry (Online-SPE-UHPLC-MS/MS) method for the analysis of 28 illegal drugs in sewage. To achieve this, 28 isotope internal standards (ISTDs) were added to 3 mL sewage samples, the pH was adjusted to 7-8 using hydrochloric acid or 20% ammonia water, followed by centrifugation, filtration, and analysis using UHPLC-MS/MS. The results indicated an excellent linearity of 1-300 ng L-1, and cotinine in the concentration range of 20-6000 ng L-1, linear correlation coefficient R2 > 0.995, with the limit of detection (LOD) of 0.01-6 ng L-1, and a limit of quantification (LOQ) of 0.1-20 ng L-1. The addition of three concentrates of low (2 ng L-1/40 ng L-1), medium (20 ng L-1/400 ng L-1), and high concentration (200 ng L-1/4000 ng L-1) demonstrated the matrix effect of the target compound between ± 22.0%. The extraction recovery was 70.0-119.4%, and a percent accuracy of 75.7-118.1%. Similarly, the intra- and inter-day precisions were 1.8-20.0% and 1.5-18.9%, respectively. The results cemented the sensitivity, accuracy, reliability, strong specificity, and reproducibility, which can be used to screen 28 illegal drugs in sewage for trace analysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido