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Safety and efficacy comparison of remimazolam and propofol for intravenous anesthesia during gastroenteroscopic surgery of older patients: A meta-analysis.
Li, Fang-Zhuo; Zhao, Cheng; Tang, Yi-Xun; Liu, Ji-Tong.
Afiliación
  • Li FZ; Department of Anesthesiology, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha 410005, Hunan Province, China.
  • Zhao C; Department of Anesthesiology, Zhangjiajie People's Hospital, Zhangjiajie 427000, Hunan Province, China.
  • Tang YX; Department of Anesthesiology, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha 410005, Hunan Province, China.
  • Liu JT; Department of Anesthesiology, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha 410005, Hunan Province, China. liujitong008@163.com.
World J Clin Cases ; 12(7): 1272-1283, 2024 Mar 06.
Article en En | MEDLINE | ID: mdl-38524507
ABSTRACT

BACKGROUND:

Remimazolam is characterized by rapid action and inactive metabolites. It is used as the general anesthetic for many clinical surgeries. In this study, we performed a meta-analysis to evaluate whether remimazolam is superior to propofol for gastroenteroscopy in older patients.

AIM:

To compare the adverse events and efficacy of remimazolam and propofol during gastroenteroscopy in older adults.

METHODS:

The PubMed, Web of Science, the Cochrane Library databases were queried for the relevant key words "remimazolam," "and propofol," "and gastrointestinal endoscopy or gastroscopy." The search scope was "Title and Abstract," and the search was limited to human studies and publications in English. Seven studies wherein remimazolam and propofol were compared were included for the meta-analysis.

RESULTS:

We selected seven randomized controlled trials involving 1445 cases for the analysis. Remimazolam reduced the hypotension (relative risk, RR = 0.44, 95%CI 0.29-0.66, P = 0.000), respiratory depression (RR = 0.46, 95%CI 0.30-0.70, P = 0.000), injection pain (RR = 0.12, 95%CI 0.05-0.25, P = 0.000), bradycardia (RR = 0.37, 95%CI 0.24-0.58, P = 0.000), and time to discharge [weighted mean difference (WMD) = -0.58, 95%CI -0.97 to -0.18, P = 0.005], compared to those after propofol administration. No obvious differences were observed for postoperative nausea and vomiting (RR = 1.09, 95%CI 0.97-1.24, P = 0.151), dizziness (RR = 0.77, 95%CI 0.43-1.36, P = 0.361), successful sedation rate (RR = 0.96, 95%CI 0.93-1.00, P = 0.083), or the time to become fully alert (WMD = 0.00, 95%CI -1.08-1.08, P = 0.998).

CONCLUSION:

Remimazolam appears to be safer than propofol for gastroenteroscopy in older adults. However, further studies are required to confirm these findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Clin Cases Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Clin Cases Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos