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It's not all about flagella - sticky invasion by pathogenic spirochetes.
Strnad, Martin; Koizumi, Nobuo; Nakamura, Shuichi; Vancová, Marie; Rego, Ryan O M.
Afiliación
  • Strnad M; Institute of Parasitology, Biology Centre CAS, Branisovská 31, 37005, Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, Branisovská 1760, 37005, Ceské Budejovice, Czech Republic. Electronic address: strnad@paru.cas.cz.
  • Koizumi N; Department of Bacteriology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
  • Nakamura S; Department of Applied Physics, Graduate School of Engineering, Tohoku University, 6-6-05 Aoba, Aoba-ku, Sendai, Miyagi 980-8579, Japan.
  • Vancová M; Institute of Parasitology, Biology Centre CAS, Branisovská 31, 37005, Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, Branisovská 1760, 37005, Ceské Budejovice, Czech Republic.
  • Rego ROM; Institute of Parasitology, Biology Centre CAS, Branisovská 31, 37005, Ceské Budejovice, Czech Republic; Faculty of Science, University of South Bohemia, Branisovská 1760, 37005, Ceské Budejovice, Czech Republic.
Trends Parasitol ; 40(5): 378-385, 2024 May.
Article en En | MEDLINE | ID: mdl-38523038
ABSTRACT
Pathogenic spirochetes cause a range of serious human diseases such as Lyme disease (LD), syphilis, leptospirosis, relapsing fever (RF), and periodontal disease. Motility is a critical virulence factor for spirochetes. From the mechanical perspective of the infection, it has been widely believed that flagella are the sole key players governing the migration and dissemination of these pathogens in the host. Here, we highlight the important contribution of spirochetal surface-exposed adhesive molecules and their dynamic interactions with host molecules in the process of infection, specifically in spirochetal swimming and crawling migration. We believe that these recent findings overturn the prevailing view depicting the spirochetal body to be just an inert elastic bag, which does not affect spirochetal cell locomotion.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Spirochaetales / Flagelos Límite: Animals / Humans Idioma: En Revista: Trends Parasitol Asunto de la revista: PARASITOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Spirochaetales / Flagelos Límite: Animals / Humans Idioma: En Revista: Trends Parasitol Asunto de la revista: PARASITOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido