Your browser doesn't support javascript.
loading
The impact of mental health on health-related quality of life in patients with NF2-related Schwannomatosis.
Freier, Anna; Lawson McLean, Anna C; Loeschner, Denise; Rosahl, Steffen K; Kruse, Johannes.
Afiliación
  • Freier A; Department of Psychosomatic Medicine and Psychotherapy, Phillips University Marburg, Marburg, Germany. anna.freier@staff.uni-marburg.de.
  • Lawson McLean AC; Department of Neurosurgery, Helios Klinikum Erfurt, Health and Medical University (HMU), Erfurt, Germany.
  • Loeschner D; Department of Neurosurgery, University Hospital Jena, Jena, Germany.
  • Rosahl SK; Department of Neurosurgery, Helios Klinikum Erfurt, Health and Medical University (HMU), Erfurt, Germany.
  • Kruse J; Department of Neurosurgery, Helios Klinikum Erfurt, Health and Medical University (HMU), Erfurt, Germany.
Sci Rep ; 14(1): 6934, 2024 03 23.
Article en En | MEDLINE | ID: mdl-38521834
ABSTRACT
NF2-related schwannomatosis (NF2-SWN) is a rare genetic disorder and is associated with progressive morbidities. This study aimed to investigate the relationship between NF2-SWN disease severity, health-related Quality of Life (QoL), and mental health aspects of patients. Standardised questionnaires assessing mental health problems (symptoms of depression, anxiety, and somatic burden), psychological factors (resilience, loneliness, and personality functioning), and health-related QoL were administered to 97 patients with NF2-SWN. The results of these questionnaires were compared with physician-rated disease severity. Questionnaires were completed by 77 patients. Physician-rated disease severity scores were available for 55 patients. NF2-SWN patients showed a high prevalence of clinically relevant symptoms of depression (30%), anxiety (16%), and somatic burden (32%). Almost all variables showed moderate to high correlations with NF2-SWN-related QoL. NF2-SWN-related QoL was associated with physician-reported disease severity (r = 0.614). In the stepwise hierarchical linear regression analysis, a significant model with four predictors (disease severity type, depression symptoms, personality functioning, and gender) explained 64% of the variance in NF2-SWN-related QoL. Our results showed a strong association between NF2-SWN-related QoL and depression symptoms. Moreover, personality functioning is an important influencing factor, representing a modifiable construct that can be targeted by prevention programs or psychotherapy.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Neurofibromatosis 2 / Neurofibromatosis / Neurilemoma Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Neurofibromatosis 2 / Neurofibromatosis / Neurilemoma Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido