Measuring the replicability of our own research.
J Neurosci Methods
; 406: 110111, 2024 06.
Article
en En
| MEDLINE
| ID: mdl-38521128
ABSTRACT
In the study of transgenic mouse models of neurodevelopmental and neurodegenerative disorders, we use batteries of tests to measure deficits in behaviour and from the results of these tests, we make inferences about the mental states of the mice that we interpret as deficits in "learning", "memory", "anxiety", "depression", etc. This paper discusses the problems of determining whether a particular transgenic mouse is a valid mouse model of disease X, the problem of background strains, and the question of whether our behavioural tests are measuring what we say they are. The problem of the reliability of results is then discussed are they replicable between labs and can we replicate our results in our own lab? This involves the study of intra- and inter- experimenter reliability. The variables that influence replicability and the importance of conducting a complete behavioural phenotype sensory, motor, cognitive and social emotional behaviour are discussed. Then the thorny question of failure to replicate is examined Is it a curse or a blessing? Finally, the role of failure in research and what it tells us about our research paradigms is examined.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Modelos Animales de Enfermedad
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neurosci Methods
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos