Your browser doesn't support javascript.
loading
Highly selective and sensitive molecularly imprinted sensors for the electrochemical assay of quercetin in methanol extracts of Rubus sanctus and Fragaria vesca.
Hurkul, M Mesud; Cetinkaya, Ahmet; Yayla, Seyda; Kaya, S Irem; Budak, Fatma; Tok, Kenan Can; Gumustas, Mehmet; Uzun, Lokman; Ozkan, Sibel A.
Afiliación
  • Hurkul MM; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Ankara, Turkiye.
  • Cetinkaya A; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkiye; Ankara University, Graduate School of Health Sciences, Ankara, Turkiye.
  • Yayla S; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Ankara, Turkiye; Ankara University, Graduate School of Health Sciences, Ankara, Turkiye.
  • Kaya SI; University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkiye.
  • Budak F; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkiye; Ankara University, Graduate School of Health Sciences, Ankara, Turkiye.
  • Tok KC; Ankara University, Institute of Forensic Sciences, Department of Forensic Toxicology, Ankara, Turkiye.
  • Gumustas M; Ankara University, Institute of Forensic Sciences, Department of Forensic Toxicology, Ankara, Turkiye.
  • Uzun L; Hacettepe University, Faculty of Science, Department of Chemistry, Ankara, Turkiye.
  • Ozkan SA; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Turkiye. Electronic address: ozkan@pharmacy.ankara.edu.tr.
Talanta ; 273: 125883, 2024 Jun 01.
Article en En | MEDLINE | ID: mdl-38521023
ABSTRACT
Quercetin (QUE) is a powerful antioxidant and one of the common phenolic compounds found in plants, vegetables, and fruits, which has shown many pharmacological activities. The complex nature of the matrix in which QUE is found and its importance and potential uses in diverse applications force the researchers to develop selective and sensitive sensors. In the present work, a novel molecularly imprinted polymer (MIP)-based electrochemical sensor was fabricated for the selective and sensitive determination of the QUE in plant extracts and food supplements. Tryptophan methacrylate (TrpMA) was chosen as the functional monomer, whereas the photopolymerization (PP) method was applied using a glassy carbon electrode (GCE). Electrochemical and morphological characterizations of the developed sensor (TrpMA@QUE/MIP-GCE) were performed using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM). The linear range of the developed sensor was determined to be in the range of 1.0-25 pM, while the limit of detection (LOD) was calculated to be 0.235 pM. In conclusion, The TrpMA@QUE/MIP-GCE sensor might be classified as a promising platform for selective and sensitive determination of QUE not only in plant extracts but also in commercial food supplements because of its reliability, reproducibility, repeatability, stability, and fast response time.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragaria / Impresión Molecular / Rubus Idioma: En Revista: Talanta Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragaria / Impresión Molecular / Rubus Idioma: En Revista: Talanta Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos