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Healthy Lifestyle Is a Protective Factor from Moderate and Severe Relapses and Steroid Use in Inflammatory Bowel Disease: A Prospective Cohort Study.
García-Mateo, Sandra; Martínez-Domínguez, Samuel Jesús; Gargallo-Puyuelo, Carla Jerusalén; Gallego, Beatriz; Alfambra, Erika; Escuin, María; García-Mateo, Sergio; López, Julia; Gomollón, Fernando.
Afiliación
  • García-Mateo S; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain.
  • Martínez-Domínguez SJ; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • Gargallo-Puyuelo CJ; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain.
  • Gallego B; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • Alfambra E; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain.
  • Escuin M; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • García-Mateo S; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • López J; Aragón Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
  • Gomollón F; Department of Gastroenterology, Lozano Blesa University Clinical Hospital, 50009 Zaragoza, Spain.
Inflamm Bowel Dis ; 2024 Mar 23.
Article en En | MEDLINE | ID: mdl-38520736
ABSTRACT

BACKGROUND:

A healthy lifestyle, including good adherence to a Mediterranean diet (MD) and regular physical exercise, may be an important factor during the course of inflammatory bowel disease (IBD). Our aim is to determine whether adherence to MD, physical activity, and the combination of both can impact on IBD course.

METHODS:

This prospective cohort study includes 693 IBD outpatients who were in remission with a median follow-up time of 27 months (interquartile range 22-29 months). Each patient completed a survey to assess their adherence to the MD and physical activity. Healthy lifestyle was considered to be a proper adherence to both MD and an active lifestyle. Relapse during follow-up, severity of relapses, need for systemic steroids, and therapy changes were recorded.

RESULTS:

During the follow-up period, 188 patients (27.1%) experienced relapse, of which 56.1% were moderate or severe. Among patients with relapse, 85 (45%) required treatment with corticosteroids, and 15 (7.9%) were hospitalized. Patients with ulcerative colitis (CU) were more adherent to healthy lifestyle than patients with Crohn's disease (P = .011). Healthy lifestyle was associated with lower risk of moderate and severe relapses (adjusted Hazard ratio [aHR], 0.250; 95% confidence interval [CI], 0.093-0.670) and steroids use (aHR 0.292; 95% CI, 0.103-0.828) in IBD patients and with lower risk of moderate and severe relapses (aHR 0.270; 95% CI, 0.093-0.789) in UC patients.

CONCLUSIONS:

Healthy lifestyle has a favorable influence on promoting a milder disease course, and thus should be a crucial part of clinical management of patients with IBD.
Healthy lifestyle including adherence to a Mediterranean diet and physical exercise has a favorable influence on promoting a milder disease course and thus should be a crucial part of clinical management of patients with IBD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido