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Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (µCAPs).
Delavari, Farnaz; Sandini, Corrado; Kojovic, Nada; Saccaro, Luigi F; Eliez, Stephan; Van De Ville, Dimitri; Bolton, Thomas A W.
Afiliación
  • Delavari F; Developmental Imaging and Psychopathology Laboratory, University of Geneva School of Medicine, Geneva, Switzerland.
  • Sandini C; Neuro-X Institute, École Polytechnique FÉdÉrale de Lausanne, Geneva, Switzerland.
  • Kojovic N; Developmental Imaging and Psychopathology Laboratory, University of Geneva School of Medicine, Geneva, Switzerland.
  • Saccaro LF; Autism Brain and Behavior Lab, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Eliez S; Faculty of Medicine, Psychiatry Department, University of Geneva, Geneva, Switzerland.
  • Van De Ville D; Psychiatry Department, Geneva University Hospital, Geneva, Switzerland.
  • Bolton TAW; Developmental Imaging and Psychopathology Laboratory, University of Geneva School of Medicine, Geneva, Switzerland.
Hum Brain Mapp ; 45(5): e26649, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38520364
ABSTRACT
The temporal variability of the thalamus in functional networks may provide valuable insights into the pathophysiology of schizophrenia. To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro-co-activation patterns (µCAPs) and employed this method on the human genetic model of schizophrenia 22q11.2 deletion syndrome (22q11.2DS). Participants underwent resting-state functional MRI and a data-driven iterative process resulting in the identification of six whole-brain µCAPs with specific activity patterns within the thalamus. Unlike conventional methods, µCAPs extract dynamic spatial patterns that reveal partially overlapping and non-mutually exclusive functional subparts. Thus, the µCAPs method detects finer foci of activity within the initial seed region, retaining valuable and clinically relevant temporal and spatial information. We found that a µCAP showing co-activation of the mediodorsal thalamus with brain-wide cortical regions was expressed significantly less frequently in patients with 22q11.2DS, and its occurrence negatively correlated with the severity of positive psychotic symptoms. Additionally, activity within the auditory-visual cortex and their respective geniculate nuclei was expressed in two different µCAPs. One of these auditory-visual µCAPs co-activated with salience areas, while the other co-activated with the default mode network (DMN). A significant shift of occurrence from the salience+visuo-auditory-thalamus to the DMN + visuo-auditory-thalamus µCAP was observed in patients with 22q11.2DS. Thus, our findings support existing research on the gatekeeping role of the thalamus for sensory information in the pathophysiology of psychosis and revisit the evidence of geniculate nuclei hyperconnectivity with the audio-visual cortex in 22q11.2DS in the context of dynamic functional connectivity, seen here as the specific hyper-occurrence of these circuits with the task-negative brain networks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Esquizofrenia / Síndrome de DiGeorge Límite: Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Esquizofrenia / Síndrome de DiGeorge Límite: Humans Idioma: En Revista: Hum Brain Mapp Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos