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Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma.
Tian, Wenjuan; Cao, Siyu; Zhang, Wei; Quan, Chenlian; Zhang, Meiqin; Huang, Yan.
Afiliación
  • Tian W; Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.
  • Cao S; Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Zhang W; Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.
  • Quan C; Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Zhang M; Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.
  • Huang Y; Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Gynecol Endocrinol ; 40(1): 2317270, 2024 Feb 12.
Article en En | MEDLINE | ID: mdl-38518807
ABSTRACT

AIMS:

The aim of this study was to investigate the impact of three single nucleotide polymorphisms (SNPs) within X-Ray Repair Cross Complementary Group 2 (XRCC2) gene and additional gene- abdominal obesity (AO) interaction with endometrial carcinoma (EC) risk.

METHODS:

Hardy-Weinberg equilibrium was tested for all participants by using SNPstats (online software http//bioinfo.iconcologia.net/SNPstats). The best SNP-SNP and gene-AO interaction combination among three SNPs within XRCC2 gene and AO was screened using generalized multifactor dimensionality reduction (GMDR).

RESULTS:

We employed the logistic regression analysis showed that rs718282-T allele is associated with increased EC risk, adjusted ORs (95%CI) were 1.67 (1.23-2.04). However, we did not find statistical association between rs3218536, and rs3218384 and EC susceptibility. GMDR analysis was used for SNP-SNP- and gene-abdominal obesity analysis. The cross-validation consistency and the testing accuracy for the interaction were calculated. The two-locus model between rs718282 and AO had a testing accuracy of 60.11%, which was significant at the p < .001 level, and this two- locus model was considered as the best model. It provided statistical evidence for rs718282 gene-AO interaction effects. The results indicated that AO influenced the EC risk depending on the rs718282 genotypes. Compared with non- AO subjects with rs718282-CC genotype, AO subjects with rs718282-CT or TT genotype had the highest EC risk, OR (95%CI) was 2.83 (1.67 - 4.02), after covariates adjustment.

CONCLUSIONS:

Both the rs718282- T allele, and its interaction with AO were associated with increased EC risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Predisposición Genética a la Enfermedad Límite: Female / Humans País/Región como asunto: Asia Idioma: En Revista: Gynecol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / GINECOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Predisposición Genética a la Enfermedad Límite: Female / Humans País/Región como asunto: Asia Idioma: En Revista: Gynecol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / GINECOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido