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SP-8356 inhibits acute lung injury by suppressing inflammatory cytokine production and immune cell infiltration.
Nguyen, Thai-Uy; Hurh, Sunghoon; In, Soyeon; Nguyen, Lan Phuong; Cho, Minyeong; Mykhailova, Kateryna; Kim, Hong-Rae; Ham, Byung-Joo; Choi, Yongseok; Kim, Won-Ki; Hwang, Jong-Ik.
Afiliación
  • Nguyen TU; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Hurh S; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • In S; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Nguyen LP; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Cho M; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Mykhailova K; Department of Biotechnology, College of Life Sciences Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • Kim HR; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Ham BJ; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea; Department of Psychiatry, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
  • Choi Y; Department of Biotechnology, College of Life Sciences Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • Kim WK; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea; Institute for Inflammation Control, Korea University, Seoul 02841, Republic of Korea. Electronic address: wonki@korea.ac.kr.
  • Hwang JI; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea. Electronic address: hjibio@korea.ac.kr.
Int Immunopharmacol ; 131: 111847, 2024 Apr 20.
Article en En | MEDLINE | ID: mdl-38518593
ABSTRACT
This study investigated the anti-inflammatory and protective properties of SP-8356, a synthetic derivative of (1S)-(-)-verbenone, in a mouse model of LPS-induced acute lung injury (ALI). By targeting intracellular signaling pathways and inflammatory responses, SP-8356 demonstrated a potent ability to attenuate deleterious effects of proinflammatory stimuli. Specifically, SP-8356 effectively inhibited the activation of crucial signaling molecules such as NF-κB and Akt, and subsequently dampened the expression of inflammatory cytokines in various lung cellular components. Intervention with SP-8356 treatment also preserved the structural integrity of the epithelial and endothelial barriers. By reducing immune cell infiltration into inflamed lung tissue, SP-8356 exerted a broad protective effect against ALI. These findings position SP-8356 as a promising therapeutic candidate for pulmonary inflammatory diseases that cause ALI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesión Pulmonar Aguda / Monoterpenos Bicíclicos Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesión Pulmonar Aguda / Monoterpenos Bicíclicos Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos