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Longitudinal study of insomnia, suicidal ideation, and psychopathology in schizophrenia.
Ketcham, Evan; Schooler, Nina R; Severe, Joanne B; Buckley, Peter F; Miller, Brian J.
Afiliación
  • Ketcham E; Medical College of Georgia, Augusta University, Augusta, GA, United States.
  • Schooler NR; SUNY Downstate Health Sciences Center, Brooklyn, NY, United States.
  • Severe JB; Research Consultant, Rockville, MD, United States.
  • Buckley PF; Chancellor's Office, University of Tennessee Health Sciences Center, Memphis, TN, United States.
  • Miller BJ; Medical College of Georgia, Augusta University, Augusta, GA, United States; Department of Psychiatry and Health Behavior, Augusta University, Augusta, GA, United States. Electronic address: brmiller@augusta.edu.
Schizophr Res ; 267: 34-38, 2024 May.
Article en En | MEDLINE | ID: mdl-38518475
ABSTRACT

OBJECTIVE:

Insomnia is a common comorbidity in schizophrenia. Increasing cross-sectional evidence suggests an association between insomnia and suicidal ideation (SI) and symptom severity in schizophrenia. We investigated longitudinal associations over 3 months between insomnia, suicidal ideation, and symptom severity in a group of patients with chronic schizophrenia.

METHOD:

We performed a secondary analysis of data from n = 305 participants from the Preventing Relapse Oral Antipsychotics Compared to Injectables Evaluating Efficacy (PROACTIVE) schizophrenia trial using regression models.

RESULTS:

The prevalence of moderate-to-severe insomnia was 17.7 % at baseline and 13.6 % at 3 months, respectively. The prevalence of SI was 22 % at baseline and 22.5 % at 3 months. After controlling for potential confounders, improved SI from baseline to 3 months was associated with both baseline moderate-to-severe insomnia (OR = 3.81, 95 % CI 1.11-13.12, p = 0.034) and improvement in insomnia (OR = 3.50, 95 % CI 1.23-9.92, p = 0.013). Worsening SI from baseline to 3 months was associated with worsening insomnia (OR = 3.50, 95 % CI 1.23-9.92, p = 0.013), but not baseline insomnia. Improvement in BPRS total score from baseline to 3 months was associated with improvement in insomnia (ß = 0.17, p = 0.029), but not baseline insomnia.

CONCLUSION:

Insomnia is common in patients with chronic schizophrenia and insomnia showed significant associations with SI and psychopathology. Clinicians should consider insomnia when assessing suicide risk in patients with schizophrenia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Ideación Suicida / Trastornos del Inicio y del Mantenimiento del Sueño Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Ideación Suicida / Trastornos del Inicio y del Mantenimiento del Sueño Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos