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PFAS alters placental arterial vasculature in term human placentae: A prospective pregnancy cohort study.
Chowdhury, Sadia Firoza; Prout, Nashae; Rivera-Núñez, Zorimar; Barrett, Emily; Brunner, Jessica; Duberstein, Zoe; Kannan, Kurunthachalam; Salafia, Carolyn M; Shah, Ruchit; Miller, Richard K; O'Connor, Thomas G.
Afiliación
  • Chowdhury SF; Wynne Center for Family Research, University of Rochester, 601 Elmwood Avenue., Rochester, NY, 14642, USA; Translational Biomedical Sciences Program, University of Rochester, 601 Elmwood Avenue., Rochester, NY, 14642, USA. Electronic address: sadia_chowdhury@urmc.rochester.edu.
  • Prout N; Wynne Center for Family Research, University of Rochester, 601 Elmwood Avenue., Rochester, NY, 14642, USA; Toxicology Graduate Program, University of Rochester, 601 Elmwood Avenue., Rochester, NY, 14642, USA. Electronic address: Nashae_prout@urmc.rochester.edu.
  • Rivera-Núñez Z; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, 683 Hoes Lane West, Piscataway, NJ, 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Rd., Piscataway, NJ, 08854, USA. Electronic address: Zr69@eohsi.rutgers.edu.
  • Barrett E; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, 683 Hoes Lane West, Piscataway, NJ, 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Rd., Piscataway, NJ, 08854, USA; Department of Obstetrics and Gynecology, Uni
  • Brunner J; Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, USA. Electronic address: Jessica_brunner@urmc.rochester.edu.
  • Duberstein Z; Wynne Center for Family Research, University of Rochester, 601 Elmwood Avenue., Rochester, NY, 14642, USA; Psychology, University of Rochester, Meliora Hall, P.O. Box 270266, Rochester, NY, 14627, USA. Electronic address: zduberst@ur.rochester.edu.
  • Kannan K; Department of Pediatrics and Department of Environmental Medicine, New York University Grossman School of Medicine, 550 1st Ave., New York, NY, 10016, USA. Electronic address: Kurunthachalam.Kannan@health.ny.gov.
  • Salafia CM; Placental Analytics LLC, 187 Overlook Circle, New Rochelle, NY, 10804, USA; Institute for Basic Research, 1550 Forest Hill Road, Staten Island, NY 10314, USA; New York Presbyterian- Brooklyn Methodist Hospital, 550 6th Street, Brooklyn, NY, 11215, USA; Queens Hospital Center, 82-68 164th Street, Que
  • Shah R; Placental Analytics LLC, 187 Overlook Circle, New Rochelle, NY, 10804, USA. Electronic address: Ruchit.shah27@gmail.com.
  • Miller RK; Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, USA. Electronic address: Richardk_miller@urmc.rochester.edu.
  • O'Connor TG; Wynne Center for Family Research, University of Rochester, 601 Elmwood Avenue., Rochester, NY, 14642, USA; Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, USA; Psychology, University of Rochester, Meliora Hall, P.O. Box 270266, Rochester, NY, 14627,
Placenta ; 149: 54-63, 2024 04.
Article en En | MEDLINE | ID: mdl-38518389
ABSTRACT

INTRODUCTION:

Perfluoroalkyl substances (PFAS) are synthetic chemicals used in industrial and consumer goods that are widely detected in human populations and are associated with adverse health outcomes, including perinatal health risks and child health. One mechanism of influence may be the impact of PFAS exposure on placental structure and function.

OBJECTIVES:

The objective of this study is to investigate the relationship between maternal prenatal exposure to PFAS and measures of placental vascularization, and to assess whether changes in vascularization play a role in mediating the impact of PFAS on birth outcomes.

METHODS:

Using data from a prospective cohort study, we examined associations between second trimester PFAS (individually and as mixtures using Bayesian kernel machine regression) and placental arterial vasculature in term placentae (N = 158); secondarily we evaluated the degree to which alterations in placental arterial vasculature explained associations between PFAS exposure and birth outcomes. Placental arterial vasculature features were collected from arterial tracings of each placental image.

RESULTS:

In both linear regression and mixture models, natural log-transformed perfluorooctanoic acid concentrations were negatively associated with surface vasculature, indexed by the mean distance from arterial end point to perimeter (ß = -0.23, 95% CI -0.41, -0.041); additionally, maximum arterial tortuosity was negatively associated with placental weight (ß = -0.19, 95% CI -0.34, -0.051). There were no reliable differences in effect by fetal sex.

DISCUSSION:

The findings provide some of the first evidence of PFAS exposure shaping a key measure of placental vascular function, which may underlie the impact of PFAS on perinatal and child health risks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Ácidos Alcanesulfónicos / Contaminantes Ambientales / Fluorocarburos Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Placenta Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Ácidos Alcanesulfónicos / Contaminantes Ambientales / Fluorocarburos Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Placenta Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos