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Interventions for Pancreatitis-New Approaches, Knowledge Gaps, and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Phillips, Anna Evans; Hughes, Steven J; Andersen, Dana K; Bell, Adam; Brand, Randall; Coté, Gregory A; Cowdin, Adriana; Diazgranados, Nancy; Dudeja, Vikas; Duggan, Sinead N; Fogel, Evan; Forsmark, Chris E; Freeman, A Jay; Gittes, George; Hart, Phil A; Jeon, Christie; Nealon, William; Neoptolemos, John; Palermo, Tonya M; Pandol, Stephen; Roberts, Kristen M; Rosenthal, Martin; Singh, Vikesh K; Yadav, Dhiraj; Whitcomb, David C; Zyromski, Nicholas.
Afiliación
  • Phillips AE; From the Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • Hughes SJ; Division of Surgical Oncology, Department of Surgery, University of Florida College of Medicine, Gainesville, FL.
  • Andersen DK; Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
  • Bell A; Translational Medicine and Regulatory Affairs, Theraly Fibrosis, Gaithersburg, MD.
  • Brand R; From the Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • Coté GA; Division of Gastroenterology and Hepatology, School of Medicine, Oregon Health and Science University, Portland, OR.
  • Cowdin A; The National Pancreas Foundation, Bethesda, MD.
  • Diazgranados N; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.
  • Dudeja V; Division of Surgical Oncology, Department of Surgery, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
  • Duggan SN; Department of Surgery, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Fogel E; Digestive and Liver Disorders, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
  • Forsmark CE; Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL.
  • Freeman AJ; Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, The Ohio State College of Medicine, Columbus, OH.
  • Gittes G; Pediatric General and Thoracic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • Hart PA; Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH.
  • Jeon C; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.
  • Nealon W; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, NY.
  • Palermo TM; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle Children's Research Institute, Seattle, WA.
  • Pandol S; Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA.
  • Roberts KM; School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH.
  • Rosenthal M; Department of Surgery, University of Florida, Gainesville, FL.
  • Singh VK; Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Yadav D; From the Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA.
  • Zyromski N; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.
Pancreas ; 53(4): e368-e377, 2024 Apr 01.
Article en En | MEDLINE | ID: mdl-38518063
ABSTRACT
ABSTRACT There exists no cure for acute, recurrent acute or chronic pancreatitis and treatments to date have been focused on managing symptoms. A recent workshop held by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) focused on interventions that might disrupt or perhaps even reverse the natural course of this heterogenous disease, aiming to identify knowledge gaps and research opportunities that might inform future funding initiatives for NIDDK. The breadth and variety of identified active or planned clinical trials traverses the spectrum of the disease and was conceptually grouped for the workshop into behavioral, nutritional, pharmacologic and biologic, and mechanical interventions. Cognitive and other behavioral therapies are proven interventions for pain and addiction, but barriers exist to their use. Whilst a disease specific instrument quantifying pain is now validated, an equivalent is lacking for nutrition - and both face challenges in ease and frequency of administration. Multiple pharmacologic agents hold promise. Ongoing development of Patient Reported Outcome (PRO) measurements can satisfy Investigative New Drug (IND) regulatory assessments. Despite multiple randomized clinical trials demonstrating benefit, great uncertainty remains regarding patient selection, timing of intervention, and type of mechanical intervention (endoscopic versus surgery). Challenges and opportunities to establish beneficial interventions for patients were identified.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Pancreatitis Crónica Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Pancreas Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus / Pancreatitis Crónica Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Pancreas Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos