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Omilancor mitigates the senescence of nucleus pulposus cells induced by DDP through targeting MAP2K6.
Yafeng, Fang; Xinpeng, Shi; Rong, Wei; Guofeng, Cui.
Afiliación
  • Yafeng F; Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
  • Xinpeng S; Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
  • Rong W; Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
  • Guofeng C; Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
Aging (Albany NY) ; 16(6): 5050-5064, 2024 03 20.
Article en En | MEDLINE | ID: mdl-38517363
ABSTRACT

PURPOSE:

This study explores the potential of Omilancor in treating Intervertebral Disc Degeneration (IDD) through MAP2K6 targeting.

METHODS:

We analyzed mRNA microarray datasets to pinpoint MAP2K6 as a key regulator implicated in IDD progression. Follow-up studies demonstrated that cisplatin (DDP) could prompt cellular senescence in vitro by upregulating MAP2K6 expression. Through molecular docking and other analyses, we identified Omilancor as a compound capable of binding to MAP2K6. This interaction effectively impeded the cellular senescence induced by DDP.

RESULTS:

We further showed that administration of Omilancor could significantly alleviate the degeneration of IVDs in annulus fibrosus puncture-induced rat model.

CONCLUSIONS:

Omilancor shows promise as a treatment for IDD by targeting MAP2K6-mediated cellular senescence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Degeneración del Disco Intervertebral / Anillo Fibroso / Núcleo Pulposo Límite: Animals Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Degeneración del Disco Intervertebral / Anillo Fibroso / Núcleo Pulposo Límite: Animals Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos