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Lifetime Exposure to Cigarette Smoke, B-Cell Tumor Immune Infiltration, and Immunoglobulin Abundance in Ovarian Tumors.
Hathaway, Cassandra A; Townsend, Mary K; Wang, Tianyi; Vinci, Christine; Jake-Schoffman, Danielle E; Hecht, Jonathan L; Saeed-Vafa, Daryoush; Moran Segura, Carlos; Nguyen, Jonathan V; Conejo-Garcia, Jose R; Fridley, Brooke L; Tworoger, Shelley S.
Afiliación
  • Hathaway CA; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
  • Townsend MK; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
  • Wang T; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
  • Vinci C; Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.
  • Jake-Schoffman DE; Department of Health Education and Behavior, University of Florida, Gainesville, Florida.
  • Hecht JL; Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
  • Saeed-Vafa D; Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida.
  • Moran Segura C; Advanced Analytical and Digital Laboratory, Moffitt Cancer Center, Tampa, Florida.
  • Nguyen JV; Advanced Analytical and Digital Laboratory, Moffitt Cancer Center, Tampa, Florida.
  • Conejo-Garcia JR; Advanced Analytical and Digital Laboratory, Moffitt Cancer Center, Tampa, Florida.
  • Fridley BL; Department of Immunology, Duke University School of Medicine, Durham, North Carolina.
  • Tworoger SS; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida.
Cancer Epidemiol Biomarkers Prev ; 33(6): 796-803, 2024 Jun 03.
Article en En | MEDLINE | ID: mdl-38517322
ABSTRACT

BACKGROUND:

Cigarette smoke exposure has been linked to systemic immune dysfunction, including for B-cell and immunoglobulin (Ig) production, and poor outcomes in patients with ovarian cancer. No study has evaluated the impact of smoke exposure across the life-course on B-cell infiltration and Ig abundance in ovarian tumors.

METHODS:

We measured markers of B and plasma cells and Ig isotypes using multiplex immunofluorescence on 395 ovarian cancer tumors in the Nurses' Health Study (NHS)/NHSII. We conducted beta-binomial analyses evaluating odds ratios (OR) and 95% confidence intervals (CI) for positivity of immune markers by cigarette exposure among cases and Cox proportional hazards models to evaluate hazard ratios (HR) and 95% CI for developing tumors with low (cell/Ig percentage.

RESULTS:

There were no associations between smoke exposure and B-cell or IgM infiltration in ovarian tumors. Among cases, we observed higher odds of IgA+ among ever smokers (OR, 1.54; 95% CI, 1.14-2.07) and ever smokers with no parental smoke exposure (OR, 2.03; 95% CI, 1.18-3.49) versus never smokers. Women with parental cigarette smoke exposure versus not had higher risk of developing ovarian cancer with low IgG+ (HR, 1.51; 95% CI, 1.10-2.09), whereas ever versus never smokers had a lower risk (HR, 0.74; 95% CI, 0.56-0.99).

CONCLUSIONS:

Ever smoking was associated with increased odds of IgA in ovarian tumors. IMPACT IgA has been associated with improved ovarian cancer outcomes, suggesting that although smoking is associated with poor outcomes in patients with ovarian cancer, it may lead to improved tumor immunogenicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Asunto de la revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Asunto de la revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos