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Data on microRNA expression, predicted gene targets and pathway analysis in response to different concentrations of a cranberry proanthocyanidin-rich extract and its metabolite 3-(4-hydroxyphenyl)-propionic acid in intestinal Caco-2BBe1 cells.
Dimoff, Zoe; Lofft, Zoe; Liang, Fred; Chen, Siying; Massara, Paraskevi; Wu, Diana; Paetau-Robinson, Inke; Khoo, Christina; Taibi, Amel; Comelli, Elena M.
Afiliación
  • Dimoff Z; Department of Nutritional Sciences, University of Toronto, ON, Canada.
  • Lofft Z; Department of Nutritional Sciences, University of Toronto, ON, Canada.
  • Liang F; Department of Nutritional Sciences, University of Toronto, ON, Canada.
  • Chen S; Department of Nutritional Sciences, University of Toronto, ON, Canada.
  • Massara P; Department of Nutritional Sciences, University of Toronto, ON, Canada.
  • Wu D; Department of Nutritional Sciences, University of Toronto, ON, Canada.
  • Paetau-Robinson I; Ocean Spray Cranberries, Inc., Lakeville-Middleboro, MA 02349, USA.
  • Khoo C; Ocean Spray Cranberries, Inc., Lakeville-Middleboro, MA 02349, USA.
  • Taibi A; Department of Nutritional Sciences, University of Toronto, ON, Canada.
  • Comelli EM; Department of Nutritional Sciences, University of Toronto, ON, Canada.
Data Brief ; 54: 110238, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38516278
ABSTRACT
Cranberry-derived proanthocyanidin (PAC) is processed by the gut microbiota to produce 3-(4-hydroxyphenyl)-propionic acid (HPPA), among other metabolites. These data are in support of the article entitled, "Cranberry proanthocyanidin and its microbial metabolite 3,4-dihydroxyphenylacetic acid, but not 3-(4-hydroxyphenyl)-propionic acid, partially reverse pro-inflammatory microRNA responses in human intestinal epithelial cells," published in Molecular Nutrition and Food Research [1]. Here we describe data generated by nCounterⓇ Human v3 miRNA Expression Panel of RNA obtained from Caco-2BBe1 cells exposed to two different concentrations of cranberry extract rich in PAC (50 µg/ml or 100 µg/ml) or 3-(4-hydroxyphenyl)-propionic acid (5 µg/ml or 10 µg/ml) for 24 h, then stimulated with 1 ng/ml of IL-1ß or not (mock) for three hours. The raw data are publicly available at the NCBI GEO database GSE237078. This work also includes descriptive methodological procedures, treatment-responsive microRNA (miRNA) expression profiles in Caco-2BBe1 cells, and in silico mRNA gene target and pathway enrichment analyses of significantly differentially expressed miRNAs (q < 0.001). Cranberry and its components have recognized health benefits, particularly in relation to combatting inflammation and pathogenic bacterial adhesion. These data will be valuable as a reference to study the response of intestinal cells to other polyphenol-rich food sources, analyze gut microbial responses to cranberry and its metabolites in different cell lines and mammalian hosts to elucidate individualized effects, and to delineate the role of the gut microbiota in facilitating the benefits of cranberry. Moreover, these data will aid in expanding our knowledge on the mechanisms underlying the benefits of cranberry and its components.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Data Brief Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Data Brief Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos