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Deficiency of peripheral CLA+ Tregs and clinical relevance in Behcet's syndrome.
Li, Jiachen; Sun, Feng; Zhu, Danxue; Hou, Yuke; Cheng, Gong; Wang, Ping; Jin, Xu; Zhou, Wenyan; Sun, Xiaolin; Li, Zhanguo; Liu, Tian.
Afiliación
  • Li J; Department of Rheumatology and Immunology, PKUPH, Beijing, 100044, China.
  • Sun F; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
  • Zhu D; Department of Rheumatology and Immunology, PKUPH, Beijing, 100044, China.
  • Hou Y; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
  • Cheng G; Department of Rheumatology and Immunology, PKUPH, Beijing, 100044, China.
  • Wang P; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
  • Jin X; Department of Rheumatology and Immunology, PKUPH, Beijing, 100044, China.
  • Zhou W; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
  • Sun X; Department of Rheumatology and Immunology, PKUPH, Beijing, 100044, China.
  • Li Z; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, 100044, China.
  • Liu T; Department of Rheumatology and Immunology, PKUPH, Beijing, 100044, China.
Arthritis Res Ther ; 26(1): 76, 2024 Mar 21.
Article en En | MEDLINE | ID: mdl-38515127
ABSTRACT

BACKGROUND:

Autoimmune responses have been suggested to involvement in patients with Behcet's syndrome (BS). There has been growing attention towards the roles of cutaneous lymphocyte antigen (CLA)+ regular T cells (Tregs) in autoimmune diseases. The role of CLA+ Tregs in BS is still uncertain. This study aims to clarify the impact of CLA+ Tregs on BS.

METHODS:

We collected peripheral blood from a total of 107 patients with BS and 114 healthy controls (HCs). The number of CLA+ Tregs, natural killer (NK) cells, B cells, and several subtypes of CD4+ T cells were detected using flow cytometry and compared between patients and HCs.

RESULTS:

The absolute number and proportion of CLA+ Tregs among CD4+ T lymphocytes and CD4+ Tregs were lower in patients with BS than in HCs. CLA+ Tregs were positively related with NK cells (r = 0.500, P < 0.001) and B cells (r = 0.470, P < 0.001) and negatively related with effector T cells (r=-0.402, P < 0.001) in patients with BS. Patients with BS and arterial aneurysms had CLA+ Treg cell deficiency. A decreased proportion of CLA+ Tregs was associated with arterial aneurysms in patients with BS. The proportion of CLA+ Tregs in patients with BS increased with corticosteroids and immunosuppressants.

CONCLUSION:

CLA+ Tregs decrease in association with arterial aneurysm in patients with BS. CLA+ Tregs may be a predictor of response to BS treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Behçet / Antígeno Sialil Lewis X / Aneurisma Límite: Humans Idioma: En Revista: Arthritis Res Ther Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Behçet / Antígeno Sialil Lewis X / Aneurisma Límite: Humans Idioma: En Revista: Arthritis Res Ther Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido