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A prognostic signature of fatty acid metabolism-related genes for predicting survival of gastric cancer patients.
Zhao, Bochao; Jiang, Wei; Wang, Jingchao; Sheng, Guannan; Wang, Yiming; Meng, Kewei; Yang, Tao.
Afiliación
  • Zhao B; Department of Gastrointestinal Surgery, Tianjin First Central Hospital, Nankai District, Tianjin, China.
  • Jiang W; Department of Gastrointestinal Surgery, Tianjin First Central Hospital, Nankai District, Tianjin, China.
  • Wang J; Department of Gastrointestinal Surgery, Tianjin First Central Hospital, Nankai District, Tianjin, China.
  • Sheng G; Department of Gastrointestinal Surgery, Tianjin First Central Hospital, Nankai District, Tianjin, China.
  • Wang Y; Department of Gastrointestinal Surgery, Tianjin First Central Hospital, Nankai District, Tianjin, China.
  • Meng K; Department of Gastrointestinal Surgery, Tianjin First Central Hospital, Nankai District, Tianjin, China.
  • Yang T; Department of Gastrointestinal Surgery, Tianjin First Central Hospital, Nankai District, Tianjin, China.
J Biochem Mol Toxicol ; 38(4): e23687, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38515005
ABSTRACT
To analyze the expression profile of fatty acid metabolism (FAM)-related genes, identify a prognostic signature, and evaluate its clinical value for gastric cancer (GC) patients. The mRNA expression profiles of 493 FAM-related genes were obtained from TCGA database. Differentially expressed genes (DEGs) between cancer and non-cancer samples were identified, and their relationships with overall survival (OS) of GC patients were evaluated. A prognostic signature of FAM-related genes was identified by the LASSO regression model, and its predictive performance was tested by an independent external cohort. Ninety-three DEGs were identified, of which 44 were downregulated and 49 were upregulated. After optimizing risk characteristics, a prognostic signature of four FAM-related genes (ACBD5, AVPR1A, ELOVL4, and FAAH) were developed. All patients were divided into high-risk (>1.020) and low-risk groups (≤1.020) on the basis of the median risk score. Survival analysis indicated that high-risk patients had a shorter OS than low-risk patients (5-year OS rate, 26.3% vs. 45.0%, p < 0.001). The AUC values for the prediction of 3-year and 5-year OS were 0.664 and 0.624, respectively. In the GSE62254 data set, the 5-year OS rate of high-risk and low-risk patients were 44.7% versus 61.5%, respectively (p = 0.003). The AUC values were 0.632 and 0.627 at 3-year and 5-year prediction. The prognostic signature of FAM-related genes was an independent predictor of OS (hanzard ratio [HR] for TCGA cohort 1.851, 95% confidence interval [CI] 1.394-2.458, p < 0.001; HR for GSE62254 1.549, 95% CI 1.098-2.185, p = 0.013). The risk signature of four FAM-related genes was a valuable prognostic tool, and it might be helpful for clinical management and therapeutic decision of gastric cancer patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas Límite: Humans Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas Límite: Humans Idioma: En Revista: J Biochem Mol Toxicol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos