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Hydrochloric Acid-Induced Acute Lung Injury Models: Dynamic Change and Quantitative Analysis of Modified Lung Ultrasound Scoring System and High-Resolution Computed Tomography.
Guo, Jingyi; Ou, Youkuan; Liu, Qiuyue; Zeng, Kunzhang; Huang, Yijun; Yan, Fuqiang; Cai, Mingli; Lyu, Guorong.
Afiliación
  • Guo J; Department of Ultrasound, Jinjing Municipal Hospital (Shanghai Sixth People's Hospital Fujian), NO.16, Luoshan Section, Jinguang Road, Jinjiang, Quanzhou, Fujian.
  • Ou Y; Department of Radiology, Jinjing Municipal Hospital (Shanghai Sixth People's Hospital Fujian), NO.16, Luoshan Section, Jinguang Road, Jinjiang, Quanzhou, Fujian.
  • Liu Q; Department of Pathology, Jinjing Municipal Hospital (Shanghai Sixth People's Hospital Fujian), NO.16, Luoshan Section, Jinguang Road, Jinjiang, Quanzhou, Fujian.
  • Zeng K; Department of Ultrasound, Jinjing Municipal Hospital (Shanghai Sixth People's Hospital Fujian), NO.16, Luoshan Section, Jinguang Road, Jinjiang, Quanzhou, Fujian.
  • Huang Y; Department of Ultrasound, Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Licheng District, Quanzhou, Fujian.
  • Yan F; Department of Ultrasound, Jinjing Municipal Hospital (Shanghai Sixth People's Hospital Fujian), NO.16, Luoshan Section, Jinguang Road, Jinjiang, Quanzhou, Fujian.
  • Cai M; Department of Ultrasound, Jinjing Municipal Hospital (Shanghai Sixth People's Hospital Fujian), NO.16, Luoshan Section, Jinguang Road, Jinjiang, Quanzhou, Fujian.
  • Lyu G; Department of Ultrasound, Jinjing Municipal Hospital (Shanghai Sixth People's Hospital Fujian), NO.16, Luoshan Section, Jinguang Road, Jinjiang, Quanzhou, Fujian; Department of Ultrasound, Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Licheng District, Quanzho
Ultrasound Med Biol ; 50(6): 946-953, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38514364
ABSTRACT

OBJECTIVE:

Acute lung injury (ALI) has become a research hotspot due to its significant public health impact. To explore the value of the use of modified lung ultrasound (MLUS) scoring system for evaluating ALI using a rabbit model of ALI induced by hydrochloric acid (HCl) and investigate its correlation with high-resolution computed tomography (HRCT) and histopathological scores.

METHODS:

Twenty New Zealand laboratory rabbits were randomly assigned to control group (N = 5) and 3 experimental groups (N = 5 each). The control group received instillation of physiological saline, while the 3 experimental groups received 2 mL/kg of different doses of HCl instillation (mild group pH 1.5, moderate group pH 1.2, and severe group pH 1.0) through the trachea under ultrasound guidance. Pulmonary ultrasound (using Mindray Reason9 linear array probes with frequency of 6-15 mHz) and HRCT examinations were performed before modeling (0H) and at 1H, 2H, 4H, 8H, 12H after modeling. The experimental rabbits were sacrificed at 12H for examination of gross lung morphology and hematoxylin-eosin-stained histopathological sections. The correlation of MLUS scores with HRCT/histopathological scores was assessed.

RESULTS:

All rabbits in the experimental groups showed oxygenation index PaO2/FiO2<300. Successful establishment of ALI model was proven by autopsy (successful modeling rate 100%). The pathological damage increased with increase in HCl dosage. MLUS scores showed a positive correlation with HRCT scores/pathological severity. There was a strong positive correlation between MLUS scores and histopathological scores (r = 0.963, p < 0.05) as well as between HRCT scores and histopathological scores (r = 0.932, p < 0.05).

CONCLUSION:

Transtracheal injection of different dosages of HCl under ultrasound guidance induced different degrees of ALI. The MLUS scoring system can be used for semiquantitative evaluation of ALI, and is suitable as a screening tool.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Ultrasonografía / Modelos Animales de Enfermedad / Lesión Pulmonar Aguda / Ácido Clorhídrico / Pulmón Límite: Animals Idioma: En Revista: Ultrasound Med Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Ultrasonografía / Modelos Animales de Enfermedad / Lesión Pulmonar Aguda / Ácido Clorhídrico / Pulmón Límite: Animals Idioma: En Revista: Ultrasound Med Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido