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Identification of Early Hippocampal Dynamics during Recognition Memory with Independent Component Analysis.
López-Madrona, Víctor J; Trébuchon, Agnès; Mindruta, Ioana; Barbeau, Emmanuel J; Barborica, Andrei; Pistol, Costi; Oane, Irina; Alario, F Xavier; Bénar, Christian G.
Afiliación
  • López-Madrona VJ; Inst Neurosci Syst, INS, INSERM, Aix Marseille Univ, Marseille 13005, France victor.lopez-madrona@univ-amu.fr.
  • Trébuchon A; Epileptology and Cerebral Rhythmology, APHM, Timone Hospital, Marseille 13005, France.
  • Mindruta I; Functional and Stereotactic Neurosurgery, APHM, Timone Hospital, Marseille 13005, France.
  • Barbeau EJ; Physics Department, University of Bucharest, Bucharest, Romania.
  • Barborica A; Centre de Recherche Cerveau et Cognition, Université de Toulouse, Université Paul Sabatier Toulouse, Toulouse 31052, France.
  • Pistol C; Centre National de la Recherche Scientifique, CerCo (UMR5549), Toulouse 31052, France.
  • Oane I; Physics Department, University of Bucharest, Bucharest, Romania.
  • Alario FX; Physics Department, University of Bucharest, Bucharest, Romania.
  • Bénar CG; Physics Department, University of Bucharest, Bucharest, Romania.
eNeuro ; 11(4)2024 Apr.
Article en En | MEDLINE | ID: mdl-38514193
ABSTRACT
The hippocampus is generally considered to have relatively late involvement in recognition memory, its main electrophysiological signature being between 400 and 800 ms after stimulus onset. However, most electrophysiological studies have analyzed the hippocampus as a single responsive area, selecting only a single-site signal exhibiting the strongest effect in terms of amplitude. These classical approaches may not capture all the dynamics of this structure, hindering the contribution of other hippocampal sources that are not located in the vicinity of the selected site. We combined intracerebral electroencephalogram recordings from epileptic patients with independent component analysis during a recognition memory task involving the recognition of old and new images. We identified two sources with different responses emerging from the hippocampus a fast one (maximal amplitude at ∼250 ms) that could not be directly identified from raw recordings and a latter one, peaking at ∼400 ms. The former component presented different amplitudes between old and new items in 6 out of 10 patients. The latter component had different delays for each condition, with a faster activation (∼290 ms after stimulus onset) for recognized items. We hypothesize that both sources represent two steps of hippocampal recognition memory, the faster reflecting the input from other structures and the latter the hippocampal internal processing. Recognized images evoking early activations would facilitate neural computation in the hippocampus, accelerating memory retrieval of complementary information. Overall, our results suggest that the hippocampal activity is composed of several sources with an early activation related to recognition memory.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reconocimiento en Psicología / Epilepsia Límite: Humans Idioma: En Revista: ENeuro Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reconocimiento en Psicología / Epilepsia Límite: Humans Idioma: En Revista: ENeuro Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos