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The Mouse Inferior Colliculus Responds Preferentially to Non-Ultrasonic Vocalizations.
Tehrani, Mahtab; Shanbhag, Sharad; Huyck, Julia J; Patel, Rahi; Kazimierski, Diana; Wenstrup, Jeffrey J.
Afiliación
  • Tehrani M; Department of Anatomy and Neurobiology and Hearing Research Group, Northeast Ohio Medical University, Rootstown, Ohio 44272 jjw@neomed.edu mtehrani@neomed.edu.
  • Shanbhag S; Brain Health Research Institute, Kent State University, Kent, Ohio 44242.
  • Huyck JJ; Department of Anatomy and Neurobiology and Hearing Research Group, Northeast Ohio Medical University, Rootstown, Ohio 44272.
  • Patel R; Brain Health Research Institute, Kent State University, Kent, Ohio 44242.
  • Kazimierski D; Brain Health Research Institute, Kent State University, Kent, Ohio 44242.
  • Wenstrup JJ; Speech Pathology and Audiology Program, Kent State University, Kent, Ohio 44242.
eNeuro ; 11(4)2024 Apr.
Article en En | MEDLINE | ID: mdl-38514192
ABSTRACT
The inferior colliculus (IC), the midbrain auditory integration center, analyzes information about social vocalizations and provides substrates for higher level processing of vocal signals. We used multichannel recordings to characterize and localize responses to social vocalizations and synthetic stimuli within the IC of female and male mice, both urethane anesthetized and unanesthetized. We compared responses to ultrasonic vocalizations (USVs) with other vocalizations in the mouse repertoire and related vocal responses to frequency tuning, IC subdivisions, and sex. Responses to lower frequency, broadband social vocalizations were widespread in IC, well represented throughout the tonotopic axis, across subdivisions, and in both sexes. Responses to USVs were much more limited. Although we observed some differences in tonal and vocal responses by sex and subdivision, representations of vocal responses by sex and subdivision were largely the same. For most units, responses to vocal signals occurred only when frequency response areas overlapped with spectra of the vocal signals. Since tuning to frequencies contained within the highest frequency USVs is limited (<15% of IC units), responses to these vocalizations are correspondingly limited (<5% of sound-responsive units). These results highlight a paradox of USV processing in some rodents although USVs are the most abundant social vocalization, their representation and the representation of corresponding frequencies are less than lower frequency social vocalizations. We interpret this paradox in light of observations suggesting that USVs with lower frequency elements (<50 kHz) are associated with increased emotional intensity and engage a larger population of neurons in the mouse auditory system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colículos Inferiores Límite: Animals Idioma: En Revista: ENeuro Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colículos Inferiores Límite: Animals Idioma: En Revista: ENeuro Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos