Role of mRNA-binding proteins in retinal neovascularization.

Lin, Pei; Cao, Wenye; Chen, Xuemei; Zhang, Ningzhi; Xing, Yiqiao; Yang, Ning

Lin, Pei; Cao, Wenye; Chen, Xuemei; Zhang, Ningzhi; Xing, Yiqiao; Yang, Ning.

Afiliación

Lin P; Department of Ophthalmology, Renmin Hospital of Wuhan University, Jiefang Road #238, Wuhan, 430060, Hubei, China. Electronic address: linpei@whu.edu.cn.
Cao W; Department of Ophthalmology, Renmin Hospital of Wuhan University, Jiefang Road #238, Wuhan, 430060, Hubei, China. Electronic address: caowenye@whu.edu.cn.
Chen X; Department of Ophthalmology, Renmin Hospital of Wuhan University, Jiefang Road #238, Wuhan, 430060, Hubei, China. Electronic address: chenxuemei@whu.edu.cn.
Zhang N; Department of Ophthalmology, Renmin Hospital of Wuhan University, Jiefang Road #238, Wuhan, 430060, Hubei, China. Electronic address: zhangningzhi@whu.edu.cn.
Xing Y; Department of Ophthalmology, Renmin Hospital of Wuhan University, Jiefang Road #238, Wuhan, 430060, Hubei, China; Department of Ophthalmology, Aier Eye Hospital of Wuhan University, Hubei, China. Electronic address: yiqiao_xing57@whu.edu.cn.
Yang N; Department of Ophthalmology, Renmin Hospital of Wuhan University, Jiefang Road #238, Wuhan, 430060, Hubei, China. Electronic address: rootyangning@whu.edu.cn.

Exp Eye Res ; 242: 109870, 2024 May.

Article en En | MEDLINE | ID: mdl-38514023

ABSTRACT

ABSTRACT

Retinal neovascularization (RNV) is a pathological process that primarily occurs in diabetic retinopathy, retinopathy of prematurity, and retinal vein occlusion. It is a common yet debilitating clinical condition that culminates in blindness. Urgent efforts are required to explore more efficient and less limiting therapeutic strategies. Key RNA-binding proteins (RBPs), crucial for post-transcriptional regulation of gene expression by binding to RNAs, are closely correlated with RNV development. RBP-RNA interactions are altered during RNV. Here, we briefly review the characteristics and functions of RBPs, and the mechanism of RNV. Then, we present insights into the role of the regulatory network of RBPs in RNV. HuR, eIF4E, LIN28B, SRSF1, METTL3, YTHDF1, Gal-1, HIWI1, and ZFR accelerate RNV progression, whereas YTHDF2 and hnRNPA2B1 hinder it. The mechanisms elucidated in this review provide a reference to guide the design of therapeutic strategies to reverse abnormal processes.

Asunto(s)

Proteínas de Unión al ARN; Neovascularización Retiniana; Humanos; Proteínas de Unión al ARN/metabolismo; Proteínas de Unión al ARN/genética; Neovascularización Retiniana/metabolismo; Neovascularización Retiniana/genética; ARN Mensajero/genética; ARN Mensajero/metabolismo; Regulación de la Expresión Génica/fisiología; Animales

Palabras clave

Angiogenesis; Diabetic retinopathy; RNA-Binding proteins; Retinal neovascularization; Retinal vein occlusions; Retinopathy of prematurity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neovascularización Retiniana / Proteínas de Unión al ARN Límite: Animals / Humans Idioma: En Revista: Exp Eye Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

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