Snail transcription factors - Characteristics, regulation and molecular targets relevant in vital cellular activities of ovarian cancer cells.

Kielbik, Michal; Szulc-Kielbik, Izabela; Klink, Magdalena

Kielbik, Michal; Szulc-Kielbik, Izabela; Klink, Magdalena.

Afiliación

Kielbik M; Institute of Medical Biology Polish Academy of Sciences, Lodz, Poland. Electronic address: mkielbik@cbm.pan.pl.
Szulc-Kielbik I; Institute of Medical Biology Polish Academy of Sciences, Lodz, Poland.
Klink M; Institute of Medical Biology Polish Academy of Sciences, Lodz, Poland.

Biochim Biophys Acta Mol Cell Res ; 1871(5): 119705, 2024 Jun.

Article en En | MEDLINE | ID: mdl-38513918

ABSTRACT

ABSTRACT

Snail transcription factors play essential roles in embryonic development and participate in many physiological processes. However, these genes have been implicated in the development and progression of various types of cancer. In epithelial ovarian cancer, high expression of these transcription factors is usually associated with the acquisition of a more aggressive phenotype and thus, considered to be a poor prognostic factor. Numerous molecular signals create a complex network of signaling pathways regulating the expression and stability of Snails, which in turn control genes involved in vital cellular functions of ovarian cancer cells, such as invasion, survival, proliferation and chemoresistance.

Asunto(s)

Regulación Neoplásica de la Expresión Génica; Neoplasias Ováricas; Factores de Transcripción de la Familia Snail; Humanos; Factores de Transcripción de la Familia Snail/metabolismo; Factores de Transcripción de la Familia Snail/genética; Femenino; Neoplasias Ováricas/genética; Neoplasias Ováricas/metabolismo; Neoplasias Ováricas/patología; Transducción de Señal; Proliferación Celular; Animales; Carcinoma Epitelial de Ovario/genética; Carcinoma Epitelial de Ovario/metabolismo; Carcinoma Epitelial de Ovario/patología; Resistencia a Antineoplásicos/genética

Palabras clave

Chemoresistance; EMT; Epithelial ovarian cancer; Metastatic potential; Snail 1; Snail 2; Transcription factors

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Regulación Neoplásica de la Expresión Génica / Factores de Transcripción de la Familia Snail Límite: Animals / Female / Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google