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Primary metastatic melanoma of the female urethra: A case report and literature review.
Bellouki, Omar; El Aboudi, Adam; Mikou, Mohamed Ali; Boualaoui, Imad; El Sayegh, Hachem; Nouini, Yassine.
Afiliación
  • Bellouki O; Urology "A" Department, Ibn Sina University Hospital, Rabat, Morocco; Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco. Electronic address: omar_bellouki@um5.ac.ma.
  • El Aboudi A; Urology "A" Department, Ibn Sina University Hospital, Rabat, Morocco; Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco. Electronic address: adam_elaboudi@um5.ac.ma.
  • Mikou MA; Urology "A" Department, Ibn Sina University Hospital, Rabat, Morocco; Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco. Electronic address: mohamedali_mikou@um5.ac.ma.
  • Boualaoui I; Urology "A" Department, Ibn Sina University Hospital, Rabat, Morocco; Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.
  • El Sayegh H; Urology "A" Department, Ibn Sina University Hospital, Rabat, Morocco; Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.
  • Nouini Y; Urology "A" Department, Ibn Sina University Hospital, Rabat, Morocco; Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.
Int J Surg Case Rep ; 117: 109569, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38513417
ABSTRACT

BACKGROUND:

Urethral malignant melanoma is an uncommon and aggressive malignancy, frequently diagnosed at an advanced stage, posing diagnostic and therapeutic challenges. CASE PRESENTATION We present the case of a 74-year-old North African female diagnosed with primary metastatic urethral melanoma. Initial staging included a thorough physical examination, pelvic MRI, and whole-body CT scan, initially showing no signs of distant metastasis. Subsequent FDG PET/CT revealed unexpected bone metastases, prompting a significant shift in our management approach. The patient received immunotherapy with pembrolizumab, resulting in sustained metabolic stability at the six-month follow-up.

DISCUSSION:

We present recent epidemiological data and risk factors for this uncommon melanoma site. Additionally, we delve into the diagnostic challenges, underlining the expanding role of PET/CT. The discussion also covers managing options in the absence of a consensus.

CONCLUSION:

Despite several treatment choices, metastatic urethral melanoma still has a poor prognosis. This reality reflects the complexity of the disease and emphasizes the need for further research to unravel its underlying mechanisms and to establish more effective therapeutic approaches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Surg Case Rep Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Surg Case Rep Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos