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Impact of function-guided glioma treatment on oncological outcome in the elderly.
Albrecht, Carolin; Baumgart, Lea; Schroeder, Axel; Wiestler, Benedikt; Meyer, Bernhard; Krieg, Sandro M; Ille, Sebastian.
Afiliación
  • Albrecht C; Department of Neurosurgery, Technical University of Munich, Germany.
  • Baumgart L; School of Medicine, Klinikum Rechts der Isar, Ismaninger Str. 22, 81675, Munich, Germany.
  • Schroeder A; Department of Neurosurgery, Technical University of Munich, Germany.
  • Wiestler B; School of Medicine, Klinikum Rechts der Isar, Ismaninger Str. 22, 81675, Munich, Germany.
  • Meyer B; Department of Neurosurgery, Technical University of Munich, Germany.
  • Krieg SM; School of Medicine, Klinikum Rechts der Isar, Ismaninger Str. 22, 81675, Munich, Germany.
  • Ille S; Section of Diagnostic and Interventional Neuroradiology Department of Radiology, Klinikum Rechts der Isar, School of Medicine, Technische Universität München, Germany.
Brain Spine ; 4: 102742, 2024.
Article en En | MEDLINE | ID: mdl-38510620
ABSTRACT

Introduction:

Many patients with high-grade gliomas (HGG) are of older age. Research question We hypothesize that pre- and intraoperative mapping and monitoring preserve functional status in elderly patients while gross total resection (GTR) is the aim, resulting in overall survival (OS) rates comparable to the general population with HGG. Material and

methods:

We subdivided a prospective cohort of 168 patients above 65 years with eloquent high-grade gliomas into four groups ([years/cases] 1 65-69/58; 2 70-74/47; 3 75-79/43; 4 >79/20). All patients underwent preoperative noninvasive mapping, which was also used for decision-making, intraoperative neuromonitoring in 138 cases, direct cortical and/or subcortical motor mapping in 66 and 50 cases, and awake language mapping in 11 cases.

Results:

GTR and subtotal resection (STR) could be achieved in 65% and 28%, respectively. Stereotactic biopsy was performed in 8% of cases. Postoperatively, we found transient and permanent functional deficits in 13% and 11% of cases. Postoperative Karnofsky Performance Scale (KPS) did not differ between subgroups. Patients with long-term follow-up (51%) had a progression-free survival of 5.5 (1-47) months and an overall survival of 10.5 (0-86) months. Discussion and

conclusion:

The interdisciplinary glioma treatment in the elderly is less age-dependent but must be adjusted to the functional status. Function-guided surgical resections could be performed as usual, with maximal tumor resection being the primary goal. However, less network capacity in the elderly to compensate for deficits might cause higher rates of permanent deficits in this group of patients with more fast-growing malignant gliomas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Spine Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Spine Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos