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Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model.
Fu, Yang; Chen, Yong-Song; Xia, Dai-Yang; Luo, Xiao-Dan; Luo, Hao-Tong; Pan, Jie; Ma, Wei-Qing; Li, Jin-Ze; Mo, Qian-Yuan; Tu, Qiang; Li, Meng-Meng; Zhao, Yue; Li, Yu; Huang, Yi-Teng; Chen, Zhi-Xian; Li, Zhen-Jun; Bernard, Lukuyu; Dione, Michel; Zhang, You-Ming; Miao, Kai; Chen, Jian-Ying; Zhu, Shan-Shan; Ren, Jie; Zhou, Ling-Juan; Jiang, Xian-Zhi; Chen, Juan; Lin, Zhen-Ping; Chen, Jun-Peng; Ye, Hui; Cao, Qing-Yun; Zhu, Yong-Wen; Yang, Lin; Wang, Xue; Wang, Wen-Ce.
Afiliación
  • Fu Y; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Chen YS; Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
  • Xia DY; School of Marine Sciences, Sun Yat-sen University, and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, 519082, China.
  • Luo XD; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Luo HT; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Pan J; Hunan Shihua Biotech Co. Ltd., Changsha, 410000, China.
  • Ma WQ; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Li JZ; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Mo QY; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Tu Q; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, Shandong, China.
  • Li MM; School of Agricultural Science and Engineering, Liaocheng University, Liaocheng, 252000, China.
  • Zhao Y; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Li Y; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Huang YT; Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
  • Chen ZX; Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
  • Li ZJ; Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, 100080, China.
  • Bernard L; International Livestock Research Institute, Nairobi, 00100, Kenya.
  • Dione M; International Livestock Research Institute, Nairobi, 00100, Kenya.
  • Zhang YM; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, Shandong, China.
  • Miao K; Cancer Center, Faculty of Health Sciences, University of Macau, Macau, SAR, China.
  • Chen JY; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Zhu SS; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Ren J; Department of Rheumatology and Immunology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
  • Zhou LJ; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Jiang XZ; Microbiome Research Center, Moon (Guangzhou) Biotech Co. Ltd., Guangzhou, 510535, China.
  • Chen J; Microbiome Research Center, Moon (Guangzhou) Biotech Co. Ltd., Guangzhou, 510535, China.
  • Lin ZP; Shantou Baisha Research Institute of Origin Species of Poultry and Stock, Shantou, 515041, China.
  • Chen JP; Shantou Baisha Research Institute of Origin Species of Poultry and Stock, Shantou, 515041, China.
  • Ye H; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Cao QY; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Zhu YW; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
  • Yang L; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. ylin@scau.edu.cn.
  • Wang X; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, Shandong, China. wangxue@sdu.edu.cn.
  • Wang WC; State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. wangwence@scau.edu.cn.
NPJ Biofilms Microbiomes ; 10(1): 25, 2024 Mar 20.
Article en En | MEDLINE | ID: mdl-38509085
ABSTRACT
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate HUA-associated systemic purine metabolism remains unclear. In this study, we constructed a novel model of HUA in geese and investigated the mechanism by which Lactobacillus rhamnosus GG (LGG) could have beneficial effects on HUA. The administration of antibiotics and fecal microbiota transplantation (FMT) experiments were used in this HUA goose model. The effects of LGG and its metabolites on HUA were evaluated in vivo and in vitro. Heterogeneous expression and gene knockout of LGG revealed the mechanism of LGG. Multi-omics analysis revealed that the Lactobacillus genus is associated with changes in purine metabolism in HUA. This study showed that LGG and its metabolites could alleviate HUA through the gut-liver-kidney axis. Whole-genome analysis, heterogeneous expression, and gene knockout of LGG enzymes ABC-type multidrug transport system (ABCT), inosine-uridine nucleoside N-ribohydrolase (iunH), and xanthine permease (pbuX) demonstrated the function of nucleoside degradation in LGG. Multi-omics and a correlation analysis in HUA patients and this goose model revealed that a serum proline deficiency, as well as changes in Collinsella and Lactobacillus, may be associated with the occurrence of HUA. Our findings demonstrated the potential of a goose model of diet-induced HUA, and LGG and proline could be promising therapies for HUA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperuricemia / Lacticaseibacillus rhamnosus Límite: Humans Idioma: En Revista: NPJ Biofilms Microbiomes Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperuricemia / Lacticaseibacillus rhamnosus Límite: Humans Idioma: En Revista: NPJ Biofilms Microbiomes Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos