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Coarctation of Aorta With Tricuspid Aortic Valve Is Not Associated With Ascending Aortic Aneurysm.
Egbe, Alexander C; Miranda, William R; Abozied, Omar; Jain, C Charles; Burchill, Luke J; Karnakoti, Snigdha; Ahmed, Marwan H; Francois, Christopher J; Connolly, Heidi M.
Afiliación
  • Egbe AC; Department of Cardiovascular Medicine Mayo Clinic, Rochester, Minnesota, USA. Electronic address: egbe.alexander@mayo.edu.
  • Miranda WR; Department of Cardiovascular Medicine Mayo Clinic, Rochester, Minnesota, USA.
  • Abozied O; Department of Cardiovascular Medicine Mayo Clinic, Rochester, Minnesota, USA.
  • Jain CC; Department of Cardiovascular Medicine Mayo Clinic, Rochester, Minnesota, USA.
  • Burchill LJ; Department of Cardiovascular Medicine Mayo Clinic, Rochester, Minnesota, USA.
  • Karnakoti S; Department of Cardiovascular Medicine Mayo Clinic, Rochester, Minnesota, USA.
  • Ahmed MH; Department of Cardiovascular Medicine Mayo Clinic, Rochester, Minnesota, USA.
  • Francois CJ; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Connolly HM; Department of Cardiovascular Medicine Mayo Clinic, Rochester, Minnesota, USA.
J Am Coll Cardiol ; 83(12): 1136-1146, 2024 Mar 26.
Article en En | MEDLINE | ID: mdl-38508846
ABSTRACT

BACKGROUND:

Aortic aneurysm is common in patients with coarctation of aorta (COA), but it is unclear whether the risk of aortic aneurysms is due to COA or related to the presence of other risk factors such as bicuspid aortic valve (BAV) and hypertension.

OBJECTIVES:

The purpose of this study was to assess the relationship among COA, BAV, and thoracic aortic aneurysms.

METHODS:

A total of 867 patients with COA (COA group) were matched 111 to 867 patients with isolated BAV (BAV group) and 867 patients without structural heart disease (SHD) (no-SHD group). The COA group was further subdivided into a COA+BAV subgroup (n = 304 [35%]), and COA with tricuspid aortic valve (TAV) (COA+TAV subgroup [n = 563 (65%)]). Aortic dimensions were assessed at baseline and at 3, 5, and 7 years.

RESULTS:

Compared with the no-SHD group, the COA+BAV subgroup had larger aortic root diameter (37 mm [Q1-Q3 30-43 mm] vs 32 mm [Q1-Q3 27-35 mm]; P < 0.001) and mid ascending aorta dimeter (34 mm [Q1-Q3 29-40 mm] vs 28 mm [Q1-Q3 24-31 mm]; P = 0.008). Similarly, the BAV group had larger aortic root diameter (37 mm [Q1-Q3 30-42 mm] vs 32 mm [Q1-Q3 27-35 mm]; P < 0.001), and mid ascending aorta dimeter (35 mm [Q1-Q3 30-40 mm] vs 28 mm [Q1-Q3 24-31 mm]; P < 0.001). Compared with the COA+TAV subgroup, the COA+BAV subgroup and BAV group were associated with larger aortic root and mid ascending aorta diameter at baseline and follow-up. The risk of acute aortic complications was low in all groups.

CONCLUSIONS:

These findings suggest that BAV (and not COA) was associated with ascending thoracic aorta dimensions, and that patients with COA+TAV were not at a greater risk of developing ascending aortic aneurysms as compared with patients without SHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma de la Aorta / Coartación Aórtica / Enfermedad de la Válvula Aórtica Bicúspide / Aneurisma de la Aorta Ascendente / Enfermedades de las Válvulas Cardíacas Límite: Humans Idioma: En Revista: J Am Coll Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma de la Aorta / Coartación Aórtica / Enfermedad de la Válvula Aórtica Bicúspide / Aneurisma de la Aorta Ascendente / Enfermedades de las Válvulas Cardíacas Límite: Humans Idioma: En Revista: J Am Coll Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos