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Coupling of Sharp Wave Events between Zebrafish Hippocampal and Amygdala Homologs.
Blanco, Ismary; Caccavano, Adam; Wu, Jian-Young; Vicini, Stefano; Glasgow, Eric; Conant, Katherine.
Afiliación
  • Blanco I; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057 kec84@georgetown.edu ib379@georgetown.edu.
  • Caccavano A; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057.
  • Wu JY; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057.
  • Vicini S; Departments of Neuroscience, Georgetown University Medical Center, Washington, DC 20057.
  • Glasgow E; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057.
  • Conant K; Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057.
J Neurosci ; 44(17)2024 Apr 24.
Article en En | MEDLINE | ID: mdl-38508712
ABSTRACT
The mammalian hippocampus exhibits spontaneous sharp wave events (1-30 Hz) with an often-present superimposed fast ripple oscillation (120-220 Hz) to form a sharp wave ripple (SWR) complex. During slow-wave sleep or quiet restfulness, SWRs result from the sequential spiking of hippocampal cell assemblies initially activated during learned or imagined experiences. Additional cortical/subcortical areas exhibit SWR events that are coupled to hippocampal SWRs, and studies in mammals suggest that coupling may be critical for the consolidation and recall of specific memories. In the present study, we have examined juvenile male and female zebrafish and show that SWR events are intrinsically generated and maintained within the telencephalon and that their hippocampal homolog, the anterodorsolateral lobe (ADL), exhibits SW events with ∼9% containing an embedded ripple (SWR). Single-cell calcium imaging coupled to local field potential recordings revealed that ∼10% of active cells in the dorsal telencephalon participate in any given SW event. Furthermore, fluctuations in cholinergic tone modulate SW events consistent with mammalian studies. Moreover, the basolateral amygdala (BLA) homolog exhibits SW events with ∼5% containing an embedded ripple. Computing the SW peak coincidence difference between the ADL and BLA showed bidirectional communication. Simultaneous coupling occurred more frequently within the same hemisphere, and in coupled events across hemispheres, the ADL more commonly preceded BLA. Together, these data suggest conserved mechanisms across species by which SW and SWR events are modulated, and memories may be transferred and consolidated through regional coupling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Hipocampo Límite: Animals Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Hipocampo Límite: Animals Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos