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Adipokines in depressed women with and without adverse childhood experiences.
Kulakova, Eugenia; Uesekes, Berk; Hellmann-Regen, Julian; Spitzer, Carsten; Kuehl, Linn K; Otte, Christian; Wingenfeld, Katja.
Afiliación
  • Kulakova E; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany; DZPG (German Center for Mental Health), Partner Site Berlin, Germa
  • Uesekes B; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.
  • Hellmann-Regen J; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany; DZPG (German Center for Mental Health), Partner Site Berlin, Germa
  • Spitzer C; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany.
  • Kuehl LK; Clinical Psychology and Psychotherapy, Department of Psychology, MSB Medical School Berlin, Berlin, Germany.
  • Otte C; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany; DZPG (German Center for Mental Health), Partner Site Berlin, Germa
  • Wingenfeld K; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Klinik für Psychiatrie und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany; DZPG (German Center for Mental Health), Partner Site Berlin, Germa
Psychoneuroendocrinology ; 164: 107026, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38507869
ABSTRACT

BACKGROUND:

Adverse childhood experiences (ACE) elevate the risk of both major depressive disorder (MDD) and metabolic diseases. The underlying pathophysiology might include alterations of adipokine levels as a consequence of ACE. In this study, we used a full-factorial design to investigate the levels of select adipokines in women with ACE-only (n = 23), MDD-only (n = 27), ACE+MDD (n = 25) and healthy controls (HC, n = 29) to identify metabolic makers associated with vulnerability and resilience of developing MDD after ACE exposure.

METHODS:

Serum levels of adiponectin, leptin, adiponectin-to-leptin (A/L) ratio, and retinol binding protein 4 (RBP4) were measured using enzyme-linked immunosorbent assay (ELISA).

RESULTS:

Adiponectin levels did not differ between groups. Individuals with vs. without MDD showed higher leptin serum concentrations. As predicted, A/L ratio indicated lower values in individuals with vs. without ACE. RBP4 showed a more nuanced pattern with reduced levels in the ACE-only and MDD-only groups compared to HC. Furthermore, the ACE-only group showed lower RBP4 concentrations compared to ACE+MDD. These results were not accounted by BMI or medication status.

CONCLUSION:

Our results do not support the utility of adiponectin and leptin as predictors of vulnerability or resilience of developing MDD after ACE. In contrast, RBP4 might play a role in resilience towards the development of MDD following ACE. Further research on this more recently discovered adipokine seems warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Experiencias Adversas de la Infancia Límite: Female / Humans Idioma: En Revista: Psychoneuroendocrinology Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Depresivo Mayor / Experiencias Adversas de la Infancia Límite: Female / Humans Idioma: En Revista: Psychoneuroendocrinology Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido