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Stereoselective Synthesis of the Gal-α-(1→3)-Gal-ß-(1→3)-GlcNAc Trisaccharide: a new Ligand for DCAR and Mincle C-Type Lectin Receptors.
Tricomi, Jacopo; Aoun, Mike; Xu, Bingze; Holmdahl, Rikard; Richichi, Barbara.
Afiliación
  • Tricomi J; Department of Chemistry 'Ugo Schiff', University of Firenze, Via della Lastruccia 13, 50019, Sesto, Fiorentino (Firenze, Italy.
  • Aoun M; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden.
  • Xu B; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden.
  • Holmdahl R; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden.
  • Richichi B; Department of Chemistry 'Ugo Schiff', University of Firenze, Via della Lastruccia 13, 50019, Sesto, Fiorentino (Firenze, Italy.
Chembiochem ; 25(9): e202400026, 2024 May 02.
Article en En | MEDLINE | ID: mdl-38506247
ABSTRACT
In this work, we have discovered that the Gal-α-(1→3)-Gal-ß-(1→3)-GlcNAc trisaccharide, a fragment of the B antigen Type-1, is a new ligand of two C-type lectin receptors (CLRs) i. e. DCAR and Mincle which are key players in different types of autoimmune diseases. Accordingly, we report here on a straightforward methodology to access pure Gal-α-(1→3)-Gal-ß-(1→3)-GlcNAc trisaccharide. A spacer with a terminal primary amine group was included at the reducing end of the GlcNAc residue thus ensuring the further functionalization of the trisaccharide Gal-α-(1→3)-Gal-ß-(1→3)-GlcNAc.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trisacáridos / Receptores Inmunológicos / Lectinas Tipo C Límite: Humans Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trisacáridos / Receptores Inmunológicos / Lectinas Tipo C Límite: Humans Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania