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Histopathologic fate of resected pulmonary pure ground glass nodule: a systematic review and meta-analysis.
Woo, Wongi; Kang, Du-Young; Cha, Yoon Jin; Kipkorir, Vincent; Song, Seung Hwan; Moon, Duk Hwan; Shin, Jae Il; Lee, Sungsoo.
Afiliación
  • Woo W; Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Kang DY; Department of Thoracic and Cardiovascular Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea.
  • Cha YJ; Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Kipkorir V; Department of Human Anatomy, School of Medicine, University of Nairobi, Nairobi, Kenya.
  • Song SH; Department of Thoracic and Cardiovascular Surgery, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, Korea.
  • Moon DH; Department of Thoracic and Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • Shin JI; Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
  • Lee S; Severance Underwood Meta-Research Center, Institute of Convergence Science, Yonsei University, Seoul, Korea.
J Thorac Dis ; 16(2): 924-934, 2024 Feb 29.
Article en En | MEDLINE | ID: mdl-38505083
ABSTRACT

Background:

Pure ground glass nodules (GGNs) have been increasingly detected through lung cancer screening programs. However, there were limited reports about pathologic characteristics of pure GGN. Here we presented a meta-analysis of the histologic outcome and proportion analysis of pure GGN.

Methods:

This study included previous pathological reports of pure GGN published until June 14, 2022 following a systematic search. A meta-analysis estimated the summary effects and between-study heterogeneity for pathologic diagnosis of invasive adenocarcinoma (IA), minimally invasive adenocarcinoma (MIA), adenocarcinoma in situ (AIS), and atypical adenomatous hyperplasia (AAH).

Results:

This study incorporated 24 studies with 3,845 cases of pure GGN that underwent surgery. Among them, sublobar resection was undertaken in 60% of the patients [95% confidence interval (CI) 38-78%, I2=95%]. The proportion of IA in cases of resected pure GGN was 27% (95% CI 18-37%, I2=95%), and 50% of IA had non-lepidic predominant patterns (95% CI 35-65%, I2=91%). The pooled proportions of MIA, AIS, and AAH were 24%, 36%, and 11%, respectively. Among nine studies with available clinical outcomes, no recurrences or metastases was observed other than one study.

Conclusions:

The portion of IA in cases of pure GGN is significantly larger that expected. More than half of them owned invasiveness components if MIA and IA were combined. Furthermore, there were quite number of lesions with aggressive histologic patterns other than the lepidic subtype. Therefore, further attempts are necessary to differentiate advanced histologic subtype among radiologically favorable pure GGN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Thorac Dis Año: 2024 Tipo del documento: Article Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Thorac Dis Año: 2024 Tipo del documento: Article Pais de publicación: China