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Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report.
Maiorano, Antonio; Lupia, Chiara; Montenegro, Nicola; Neri, Giuseppe; Bruni, Andrea; Garofalo, Eugenio; Longhini, Federico; Crimi, Claudia; Maglio, Angelantonio; Vatrella, Alessandro; Pelaia, Girolamo; Pelaia, Corrado.
Afiliación
  • Maiorano A; Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Lupia C; Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Montenegro N; Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Neri G; Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Bruni A; Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Garofalo E; Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Longhini F; Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Crimi C; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
  • Maglio A; Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
  • Vatrella A; Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
  • Pelaia G; Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Pelaia C; Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Front Med (Lausanne) ; 11: 1357362, 2024.
Article en En | MEDLINE | ID: mdl-38504920
ABSTRACT
Beclomethasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) single inhaler extrafine triple therapy is effective for the treatment of uncontrolled asthma. Nevertheless, there is a lack of data about the use of diaphragmatic ultrasonography to monitor adult asthmatics while they are receiving inhaled treatment. We took into consideration a 78-year-old woman complaining of asthma, treated with inhaled corticosteroid/long-acting ß2-adrenergic agonist (ICS/LABA), characterized by an asthma control questionnaire-5 (ACQ-5) score and a lung function test suggestive of uncontrolled asthma. Moreover, a diaphragmatic ultrasound showed signs of high diaphragm workload. Because of these findings, we proposed to our patient a shift toward triple inhaled therapy with BDP/FF/G, and she underwent a second evaluation after 7 days of treatment. Improvements in the diaphragmatic ultrasound parameters, lung function test, and ACQ-5 score were found. In particular, we detected a reduction of thickening fraction (TF), and a normalization of the other diaphragmatic measures, indicative of a decrease in diaphragmatic workload. To our knowledge, this is the first literature report showing concomitant improvements of both lung function tests and diaphragmatic ultrasonography parameters, observed in an adult patient with uncontrolled asthma after short-term treatment with the single inhaler triple therapy BDP/FF/G.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Med (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Med (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza