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Preconception opioids interact with mouse strain to alter morphine withdrawal in the next generation.
Toorie, Anika; Hall, Claire Davidson; Vassoler, Fair M; Peltz, Gary; Byrnes, Elizabeth M.
Afiliación
  • Toorie A; Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA, USA.
  • Hall CD; Department of Biology, Rhode Island College, 600 Mount Pleasant Ave, Providence, RI, USA.
  • Vassoler FM; Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA, USA.
  • Peltz G; Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA, USA.
  • Byrnes EM; Department of Anesthesia, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA, USA.
Psychopharmacology (Berl) ; 241(7): 1435-1446, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38503843
ABSTRACT
RATIONALE Transgenerational effects of preconception morphine exposure in female rats have been reported which suggest that epigenetic modifications triggered by female opioid exposure, even when that exposure ends several weeks prior to pregnancy, has significant ramifications for their future offspring.

OBJECTIVE:

The current study compares two mouse strains with well-established genetic variation in their response to mu opioid receptor agonists, C57BL/6J (BL6) and 129S1/svlmJ (129) to determine whether genetic background modifies the impact of preconception opioid exposure.

METHODS:

Adolescent females from both strains were injected daily with morphine for a total of 10 days using an increasing dosing regimen with controls receiving saline. Several weeks after their final injection, aged-matched BL6 and 129 morphine (Mor-F0) or saline (Sal-F0) females were mated with drug naïve males to generate Mor-F1 and Sal-F1 offspring, respectively. As adults, F1 mice were made morphine dependent using thrice daily morphine injections for 4 days. On day 5, mice were administered either saline or morphine followed 3 h later by naloxone. Behavioral and physiological signs of withdrawal were then measured.

RESULTS:

Regardless of strain or sex, morphine-dependent Mor-F1 mice had significantly lower levels of withdrawal-induced corticosterone but significantly higher glucose levels when compared to Sal-F1 controls. In contrast, both strain- and preconception opioid exposure effects on physical signs of morphine dependence were observed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Abstinencia a Sustancias / Receptores Opioides mu / Analgésicos Opioides / Ratones Endogámicos C57BL / Morfina / Dependencia de Morfina Límite: Animals / Pregnancy Idioma: En Revista: Psychopharmacology (Berl) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Abstinencia a Sustancias / Receptores Opioides mu / Analgésicos Opioides / Ratones Endogámicos C57BL / Morfina / Dependencia de Morfina Límite: Animals / Pregnancy Idioma: En Revista: Psychopharmacology (Berl) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania