Mitotic bookmarking by transcription factors: be aware of redundancy.

Silva, Miguel V; Castro, Diogo S

Silva, Miguel V; Castro, Diogo S.

Afiliación

Silva MV; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Castro DS; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. Electronic address: diogo.castro@i3s.up.pt.

Trends Biochem Sci ; 49(5): 384-386, 2024 May.

Article en En | MEDLINE | ID: mdl-38503673

ABSTRACT

ABSTRACT

A recent report by Chervova, Molliex, et al. shows redundant functions for the transcription factors (TFs) ESRRB and NR5A2 as mitotic bookmarkers in mouse embryonic stem (ES) cells. These occupy some of their target sites in mitotic chromatin, ensuring their robust reactivation after cell division, including markers and regulators of pluripotency.

Asunto(s)

Mitosis; Receptores de Estrógenos; Factores de Transcripción; Animales; Ratones; Factores de Transcripción/metabolismo; Células Madre Embrionarias de Ratones/metabolismo; Células Madre Embrionarias de Ratones/citología; Cromatina/metabolismo; Humanos

Palabras clave

cell identity; mitotic bookmarking by transcription factors; nuclear receptors; pluripotency network; transcription

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Receptores de Estrógenos / Mitosis Límite: Animals / Humans Idioma: En Revista: Trends Biochem Sci Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google