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Management of glioblastoma in elderly patients: A review of the literature.
Mazarakis, Nektarios K; Robinson, Stephen D; Sinha, Priyank; Koutsarnakis, Christos; Komaitis, Spyridon; Stranjalis, George; Short, Susan C; Chumas, Paul; Giamas, Georgios.
Afiliación
  • Mazarakis NK; Royal Sussex County Hospital, University Hospitals Sussex NHS Foundation Trust, Eastern Rd, Brighton BN2 5BE, UK.
  • Robinson SD; School of Medicine RCSI, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.
  • Sinha P; Royal Sussex County Hospital, University Hospitals Sussex NHS Foundation Trust, Eastern Rd, Brighton BN2 5BE, UK.
  • Koutsarnakis C; Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.
  • Komaitis S; Department of Neurosurgery, Leeds General Infirmary, Great George Street, LS1 3EX, UK.
  • Stranjalis G; Department of Neurosurgery, Evaggelismos Hospital, Ipsilantou 45-47, Athens, Greece.
  • Short SC; Department of Neurosurgery, Evaggelismos Hospital, Ipsilantou 45-47, Athens, Greece.
  • Chumas P; Department of Neurosurgery, Evaggelismos Hospital, Ipsilantou 45-47, Athens, Greece.
  • Giamas G; Leeds Institute of Medical Research at St James's Wellcome Trust Brenner Building St James's University Hospital Leeds, LS9 7TF, UK.
Clin Transl Radiat Oncol ; 46: 100761, 2024 May.
Article en En | MEDLINE | ID: mdl-38500668
ABSTRACT
High grade gliomas are the most common primary aggressive brain tumours with a very poor prognosis and a median survival of less than 2 years. The standard management protocol of newly diagnosed glioblastoma patients involves surgery followed by radiotherapy, chemotherapy in the form of temozolomide and further adjuvant temozolomide. The recent advances in molecular profiling of high-grade gliomas have further enhanced our understanding of the disease. Although the management of glioblastoma is standardised in newly diagnosed adult patients there is a lot of debate regarding the best treatment approach for the newly diagnosed elderly glioblastoma patients. In this review article we attempt to summarise the findings regarding surgery, radiotherapy, chemotherapy, and their combination in order to offer the best possible management modality for this group of patients. Elderly patients 65-70 with an excellent functional level could be considered as candidates for the standards treatment consisting of surgery, standard radiotherapy with concomitant and adjuvant temozolomide. Similarly, elderly patients above 70 with good functional status could receive the above with the exception of receiving a shorter course of radiotherapy instead of standard. In elderly GBM patients with poorer functional status and MGMT promoter methylation temozolomide chemotherapy can be considered. For elderly patients who cannot tolerate chemotherapy, hypofractionated radiotherapy is an option. In contrast to the younger adult patients, it seems that a careful individualised approach is a key element in deciding the best treatment options for this group of patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transl Radiat Oncol Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Transl Radiat Oncol Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Irlanda