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Effect of Helicobacter Pylori Infection on Glucose Metabolism, Lipid Metabolism and Inflammatory Cytokines in Nonalcoholic Fatty Liver Disease Patients.
Xiao, Qing-Yu; Wang, Ren-Ling; Wu, Hai-Jun; Kuang, Wen-Bin; Meng, Wei-Wei; Cheng, Zhen.
Afiliación
  • Xiao QY; Department of Blood Transfusion, Shenzhen Baoan Shiyan People's Hospital, Shenzhen, 518108, China.
  • Wang RL; Department of Oncology, Kaiping Central Hospital, Jiangmen City, Guangdong Province, 529399, People's Republic of China.
  • Wu HJ; Department of Blood Transfusion, Shenzhen Baoan Shiyan People's Hospital, Shenzhen, 518108, China.
  • Kuang WB; Department of Laboratory, Longhua District Central Hospital, Shenzhen, 518110, People's Republic of China.
  • Meng WW; Department of Laboratory, Shenzhen Baoan Shiyan People's Hospital, Shenzhen, 518108, China.
  • Cheng Z; Guantian Community Healthcare Center, Shenzhen Baoan Shiyan People's Hospital, Shenzhen, Guangdong province, 518100, People's Republic of China.
J Multidiscip Healthc ; 17: 1127-1135, 2024.
Article en En | MEDLINE | ID: mdl-38500481
ABSTRACT

Objective:

To probe into the influence of Helicobacter pylori (Hp) infection on glucose metabolism, lipid metabolism, and inflammatory cytokines in patients with nonalcoholic fatty liver disease (MASLD).

Methods:

A total of 140 MASLD patients admitted to our Hospital between June 2020 and May 2021 were selected as the research objects. Based on the presence or absence of Hp infection, they were divided into the study group (73 cases with infection) and control group (67 cases without infection). Glucose metabolism indicators [fasting blood glucose (FBG), 2-hour postprandial glucose (2hPG), fasting insulin (FINS), glycated hemoglobin (HbAlc)], lipid metabolism indicators [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)], and inflammatory indicators [interleukin-37 (IL-37), interleukin-18 (IL-18)] were measured and compared between the two groups.

Results:

In terms of glucose metabolism indicators, the study group exhibited higher levels of FBG (5.84±0.49 vs 5.40±0.51, t=2.535, P=0.012), 2hPG (7.26±1.30 vs 6.50±1.53, t=3.321, P<0.001), and FINS (11.13±4.13 vs 9.12±3.72, t=3.224, P<0.001), and Insulin resistance index (HOMA-IR) (2.97±0.35 VS 2.13±0.54, t=3.761, P<0.001) and a lower level of HbAlc (5.25±0.56 vs 6.12±0.57, t=5.473, P<0.001) compared to the control group. Regarding lipid metabolism indicators, the study group exhibited higher levels of TC (5.64±1.49 vs 5.01±1.32, t=3.332, P<0.001), TG (1.89±0.34 vs 1.32±0.43, t=3.411, P<0.001), and LDL-C (3.31±0.43 vs 2.12±0.29, t=4.142, P<0.001), and a lower level of HDL-C (1.45±0.21 vs 1.78±0.42, t=4.347, P<0.001) compared to the control group. As for the inflammatory indicators, the study group exhibited higher levels of IL-37 (45.56±6.02 vs 34.02±3.28, t=9.332, P<0.001) and IL-18 (73.57±5.82 vs 60.34±4.84, t=10.141, P<0.001) compared to the control group.

Conclusion:

It is crucial to place appropriate emphasis on the impact of Hp infection on the glucose metabolism, lipid metabolism, and inflammatory response in MASLD patients, warranting careful consideration during the treatment of these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Multidiscip Healthc Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Multidiscip Healthc Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Nueva Zelanda